T5067

Anti-TRPC3 antibody produced in rabbit

Name: Anti-TRPC3 antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, lyophilized powder

Sinónimos:

Anti-Transient receptor potential cation channel, subfamily C, member 3

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UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02686005

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Nombre del producto

Anti-TRPC3 antibody produced in rabbit, affinity isolated antibody, lyophilized powder

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

concentration

≥0.6 mg/mL (after reconstitution)

technique(s)

western blot: suitable

UniProt accession no.

Q9JMI9

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

mouse ... Trpc3(22065)
rat ... Trpc3(60395)

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Este artículo	HPA006550	SAB4300077	SAB4300365
Sigma-Aldrich T5067 Anti-TRPC3 antibody produced in rabbit	Sigma-Aldrich HPA006550 Anti-ARPC3 antibody produced in rabbit	Sigma-Aldrich SAB4300077 Anti-phospho-TP53 (pSer³⁷) antibody produced in rabbit	Sigma-Aldrich SAB4300365 Anti-TP53 (Ab-18) antibody produced in rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
species reactivity rat	species reactivity rat, human, mouse	species reactivity human	species reactivity human

Biochem/physiol Actions

TRPC3 (transient receptor potential-canonical 3) participates in motility and capacitation of sperm. It is responsible for the proliferation of ovarian cancer cell in vitro and in vivo. TRPC3 plays a key role in a wide spectrum of Ca²⁺ signaling mechanisms. Elevated expression of TRPC3 has been observed in spontaneously hypertensive rats (SHR).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Transient receptor potential-canonical 3 (TRPC3) is a member of TRP superfamily. It is mainly expressed in brain. The TRPC3 gene is mapped to human chromosome 4.

Immunogen

peptide corresponding to amino acid residues 822-835 of mouse TRPC3.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Genotype of an individual single nucleotide polymorphism regulates DNA methylation at the TRPC3 alternative promoter.

Martin-Trujillo A

Epigenetics, 6, 1236-1241 (2011)

Follicle-stimulating hormone enhances the proliferation of ovarian cancer cells by activating transient receptor potential channel C3

Tao X

Endocrine-Related Cancer, 20, 415-429 (2013)

Increased Transient Receptor Potential Channel TRPC3 Expression in Spontaneously Hypertensive Rats

Liu D

American Journal of Hypertension, 18, 1503-1507 (2005)

Left Ventricular Hypertrophy Increases Susceptibility to Bupivacaine-induced Cardiotoxicity through Overexpression of Transient Receptor Potential Canonical Channels in Rats.

Hideki Hino et al.

Anesthesiology, 133(5), 1077-1092 (2020-09-12)

Local anesthetics, particularly potent long acting ones such as bupivacaine, can cause cardiotoxicity by inhibiting sodium ion channels; however, the impact of left ventricular hypertrophy on the cardiotoxicity and the underlying mechanisms remain undetermined. Transient receptor potential canonical (TRPC) channels

Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics.

Viviane Nascimento Da Conceicao et al.

iScience, 24(11), 103339-103339 (2021-11-25)

Transformation of naive macrophages into classically (M1) or alternatively (M2) activated macrophages regulates the inflammatory response. Here, we identified that distinct Ca2+ entry channels determine the IFNγ-induced M1 or IL-4-induced M2 transition. Naive or M2 macrophages exhibit a robust Ca2+

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