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Merck

T63002

2,2,2-Trifluoroethanol

ReagentPlus®, ≥99%

Synonym(s):

Trifluoroethyl alcohol

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About This Item

Linear Formula:
CF3CH2OH
CAS Number:
75-89-8
Molecular Weight:
100.04
UNSPSC Code:
12191601
NACRES:
NA.21
PubChem Substance ID:
329826635
EC Number:
200-913-6
Beilstein/REAXYS Number:
1733203
MDL number:
MFCD00004672
Assay:
≥99%
Bp:
77-80 °C (lit.)
Vapor pressure:
70 mmHg ( 25 °C)

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Product Name

2,2,2-Trifluoroethanol, ReagentPlus®, ≥99%

InChI

1S/C2H3F3O/c3-2(4,5)1-6/h6H,1H2

InChI key

RHQDFWAXVIIEBN-UHFFFAOYSA-N

SMILES string

OCC(F)(F)F

vapor density

3.5 (vs air)

vapor pressure

70 mmHg ( 25 °C)

product line

ReagentPlus®

assay

≥99%

form

liquid

autoignition temp.

~896 °F

expl. lim.

42 %

dilution

(for general lab use)

refractive index

n20/D 1.3 (lit.)

pH

7

bp

77-80 °C (lit.)

mp

−44 °C (lit.)

density

1.373 g/mL at 25 °C (lit.)

Quality Level

100

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This Item
8.0825991683426237
2,2,2-Trifluoroethanol ReagentPlus®, ≥99%

Sigma-Aldrich

T63002

2,2,2-Trifluoroethanol

2,2,2-Trifluoroethanol for synthesis

Sigma-Aldrich

8.08259

2,2,2-Trifluoroethanol

2,2,2-Trifluoroethanol analytical standard, suitable for NMR (spectroscopy)

Supelco

91683

2,2,2-Trifluoroethanol

2,2,2,Trifluoroethanol-OD 99 atom % D

Sigma-Aldrich

426237

2,2,2,Trifluoroethanol-OD

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

200

assay

≥99%

assay

≥99% (GC)

assay

≥99.5% (GC)

assay

99% (CP)

form

liquid

form

liquid

form

-

form

liquid

bp

77-80 °C (lit.)

bp

73.6 °C/1013 hPa

bp

77-80 °C (lit.)

bp

77-80 °C (lit.)

vapor density

3.5 (vs air)

vapor density

-

vapor density

3.5 (vs air)

vapor density

-

autoignition temp.

~896 °F

autoignition temp.

-

autoignition temp.

~896 °F

autoignition temp.

-

Application

2,2,2-Trifluoroethanol can be used as a solvent:
  • In the synthesis of 2-amino-3-cyano-4H-chromene and tetrahydrobenzo[b]pyran derivatives by catalyst free one-pot condensation of aldehydes, malononitrile and resorcinol or dimedone.
  • In the N-formylation of amines with formic acid in the presence of heterogeneous ZIF-8 (zeolitic imidazolate framework) catalyst.
  • In the preparation of 2-substituted-2,3-dihydro-4(1H)-quinazolinone derivatives by condensation of anthranilamide with alkyl, aryl, or heteroaryl ketones or aldehydes.
  • In the mild and selective oxidation of sulfur compounds using H2O2(hydrogen peroxide).

Features and Benefits

2,2,2-Trifluoroethanol is more acidic than ethanol due to the presence of electronegative trifluoromethyl group.

General description

2,2,2-Trifluoroethanol (TFE) is an organic compound with the chemical formula CF3CH2OH. TFE is a commonly used solvent in organic synthesis. It can also be used as a cosolvent in the experimental study of proteins and peptides.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 3 - Repr. 1B - STOT RE 2 Inhalation

target_organs

Blood

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

86.0 °F - closed cup

flash_point_c

30 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB2510
SDBB0272
STBL1867
STBK9513
STBK6004

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