• 主页
  • 查找结果
  • Intralesional antimony for single lesions of bolivian cutaneous leishmaniasis.

Intralesional antimony for single lesions of bolivian cutaneous leishmaniasis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2013-02-08)
Jaime Soto, Ernesto Rojas, Miguel Guzman, Aleida Verduguez, Winne Nena, Maria Maldonado, Mary Cruz, Lineth Gracia, Darsi Villarroel, Isidoro Alavi, Julia Toledo, Jonathan Berman
摘要

Cutaneous leishmaniasis is an ultimately self-curing disease for which systemic therapy with pentavalent antimony (Sb) is effective but with side effects. We evaluated 2 local treatments, intralesional (IL) Sb and cryotherapy, for single lesions due to Bolivian Leishmania (v.) braziliensis in a placebo-controlled study. Patients were randomized between IL Sb (650 µg/mm(2) of lesion area on days 1, 3, and 5), cryotherapy (days 1 and 14), and placebo cream (daily for 20 days) in a 3:2:3 allocation. Lesion area was measured prior to therapy, and at 1, 3, and 6 months after therapy. The criteria for lesion cure were as follows: not doubling in size at 1 month, at least 50% diminution in size at 3 months, and complete reepithelialization at 6 months. Local adverse effects were recorded. Cure rates were 21 of 30 (70%; 95% confidence interval [CI], 52%-83%) for IL Sb, 4 of 20 (20%; 95% CI, 8%-42%) for cryotherapy, and 5 of 30 (17%; 95% CI, 7%-34%) for placebo cream (P < .001 for IL Sb vs each other group). IL Sb adverse events were limited to injection site pain, with a mean value of 1.0 (mild). The comparative cure rate, small amount of drug administered, and tolerance data for IL Sb suggest that if local therapy for single L. braziliensis lesions is chosen, this treatment is attractive. Given the difficulties of performing placebo-controlled trials in the New World, the combined placebo and cryotherapy cure rate (18%; 95% CI, 10%-31%) is likely to become the standard against which future interventions for L. braziliensis are compared. NCT01300975.

材料
货号
品牌
产品描述

Sigma-Aldrich
锑, powder, -100 mesh, 99.5% trace metals basis
Sigma-Aldrich
锑, beads, 1-5 mm, low oxide, 99.999% trace metals basis