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Viral safety in bioprocessing relies on a framework of (1) preventing contamination, (2) detecting contamination, and (3) removing or inactivating viral contaminants.

Bioburden Control in Bioprocessing

Bioburden control in bioprocessing requires assessing the risks, mitigating the risks, and monitoring bioburden levels.

An Introduction to Horseradish Peroxidase (HRP) and Its Applications

Horseradish peroxidase (HRP) is an enzyme used for detecting molecules, degrading toxins, cross-linking proteins, and in diagnostics like lateral flow assays.

Cell Counting Using a Hemocytometer

Cell counting protocol using a hemocytometer for monitoring cell viability. Discover other cell counting tools such as the Scepter™ 3.0 Cell Counter.

Ultrafiltration/Diafiltration (UF/DF) in Plasmid DNA Manufacturing

How are ultrafiltration and diafiltration used in plasmid DNA manufacturing and how should you optimize this process? Learn more in our technical article and download our free eBook.

Tangential Flow Filtration in Downstream Bioprocessing

There are many options for tangential flow filtration (TFF) in downstream bioprocessing from multi-use to single-use TFF or batch TFF and single-pass TFF.

Membrane Prefilters Improve Sterilizing Filter Capacity and Process Economics in Bioprocessing

Prefilters can be used throughout bioprocessing to remove to remove particulates, improve quality and protect sterilizing filters and downstream unit operations.

Sterilizing Grade Filtration Unit Operations for Plasmid DNA Processes

We discuss the final filtration step of plasmid DNA manufacturing and its key considerations and challenges. Download our free pDNA downstream purification eBook or ask our experts.

Tangential Flow Filtration in the Antibody Drug Conjugate (ADC) Manufacturing Process

Find best practices for using Pellicon® Capsules in ADC processing as well as data from two studies using Pellicon® Capsules and Pellicon® cassettes in the ADC manufacturing process.

Single-Pass Tangential Flow Filtration Implementation and Scaling

Get practical guidance on using single-pass tangential flow filtration in your downstream process and scaling between capsules and cassettes.

Water Determination in Liquefied Petroleum Gas using GC BID and Ionic Liquid Column Watercol™

Using Watercol™ GC columns in conjunction with GC-BID can provide a reliable and practical option for Water determination in petrochemical feedstocks.

Renewable Electricity Toolkit

The Renewable Electricity Supplier Toolkit helps suppliers learn renewable electricity basics and how to bring projects to life.

Quantification and Quality Control via CCM Fingerprinting

Learn about rapid and cost-effective identification of more than 100 media formulation components using LC-MS cell culture media fingerprinting.

Scalable Tangential Flow Filtration (TFF) for Downstream Processing of Viral Vectors for Gene Therapy and Vaccine Production

Our overview of scalable tangential flow filtration for viral vector production will provide key considerations for developing and optimizing your downstream process.

Viscosity Reduction in High Concentration TFF

This overview describes how use of viscosity-reducing excipients can address viscosity challenges in high concentration tangential flow filtration (TFF) and improve process economics.

Fast and Reliable Environmental Analysis of Aldehyde and Ketone Air Pollutants

Aldehydes and ketones are ubiquitous air pollutants. Along with esters and ethers, they are major components of indoor air pollution and are therefore important for industrial hygiene applications.

Hydrocarbon Oil Index in Samples

Special mineral oil standard mixtures are gravimetrically produced for calibration.

Neonicotinoids

Learn more about Neonicotinoids - active substances used in plant protection products to control harmful insects.

New GC-MS Method for Mycotoxin Analysis

An article regarding A New GC-MS Method for Mycotoxin Analysis Using 13C-marked Mycotoxin Derivatives from Sigma-Aldrich.com

Quantitative NMR for Content Assignment of Reference Standards for Quality Control of Herbal Medicinal Products

qNMR has proven to be appropriate as a primary analytical method for the certification of natural products as reference standards for QC of herbal medicinals.

HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 280 nm)

Samplicity^® G2 Filtration System

Samplicity® G2 filtration system enhances HPLC workflow; watch video tutorials and application notes for effective sample preparation.

Analysis of Adulterated Lemon Essential Oil on the SLB-5ms

Citrus essential oils hold significant economic value. These intricate substances find primary use in the food, beverage, cosmetic, and perfume industries.

GC Analysis of a 37-Component FAME Mix on SP™-2560

A protocol for GC Analysis of a 37-Component FAME Mix on SP™-2560.

Capillary GC Columns for GC x GC

GCxGC excels in compound resolution, making it indispensable in analytical chemistry for complex samples.

Determination of Free and Total Glycerin in B100

Glycerin determination methods require multi-component calibration solutions for accurate analysis.

DRO, EPH, ETPH, GRO, PRO, PVOC, STARS, TPH, VPH? Help, I’m Trapped in Alphabet Soup!

There are three types of analyses: GRO, DRO, and TPH. The published methods are simply variations of these to meet the different analytical needs of the individual agencies.

EN 14105: GC Analysis of Glycerin Impurity in Biodiesel on MET-Biodiesel

GC Analysis of PBDE Flame-Retardant Compounds

Measuring Flows For Gas Chromatography – Volumetric vs. Mass

When choosing a flowmeter, it is essential to consider the attributes and needs of the application. This article provides information related to measuring GC flow rate by both volume and mass.

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