MAIPNTR10

MultiScreen IP Filter Plate, 0.45 µm, clear, non-sterile

This clear 96 well filter plate has a Hydrophobic PVDF membrane used for PAMPA.

• eCl@ss: 32039006
• NACRES: NB.22

Properties

• material: PVDF membrane (hydrophobic); acrylic ; flat bottom wells
• Quality Level: 400
• sterility: non-sterile
• product line: MultiScreen^®
• feature: hydrophobic; lid
• manufacturer/tradename: MultiScreen^®
• parameter: 50-250 μL sample volume (per well)
• technique(s): parallel artificial membrane permeation assay (PAMPA): suitable
• plate size: 96 wells
• well maximum volume: 300 μL
• working volume: 50-250 μL
• matrix: Immobilon^®-P
• pore size: 0.45 μm pore size
• binding type: high binding surface
• shipped in: ambient

Description

General description

Filter Code: IP

Increasing drug candidate predictability earlier in the discovery pipeline using non-cell-based assays can improve candidate throughput during the ADME stage. Non-cell-based permeability assays are predictive models for oral absorption of development candidates.

MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.

Membranes have uniform pore structure and density for reliable transport:
- Individual wells minimize candidate cross-talk
- Compatibility with automated liquid handling systems increases throughput

Permeability Assay:
- The MultiScreen Permeability plate has a polycarbonate membrane, which supports a hexane/hexadecane artificial layer for permeability assays.1

PAMPA Assay:
- The MultiScreen-IP plate has a hydrophobic PVDF membrane, which supports a lipid bilayer for PAMPA asays.2,3

MultiScreen Acceptor Plate:
- The MultiScreen Acceptor plate can be used with either plate to capture passively transported compounds. Constructed of 100% PTFE, the plate can improve LC/MS results depending on the charge of the small molecules being evaluated.

Application

Research Category
Assays

Protein

Physical form

Color Code: Clear

Other Notes

Automation Compatible: No

Legal Information

Immobilon is a registered trademark of Merck KGaA, Darmstadt, Germany

MULTISCREEN is a registered trademark of Merck KGaA, Darmstadt, Germany