MX1390

NMP

OmniSolv^®

• Synonym(s): 1-Methyl-2-Pyrrolidone, N-Methyl-2-Pyrrolidinone,NMP, Methyl Pyrrolidone
• Linear Formula: (CH₃)-NC(=O)CH₂CH₂CH₂-
• CAS Number: 872-50-4
• UNSPSC Code: 12352115
• EC Index Number: 212-828-1
• MDL number: MFCD00003193
• Assay: ≥99.7% (GC)
• Technique(s): HPLC: suitable, LC/MS: suitable, gas chromatography (GC): suitable
• Bp: 202 °C/1013 hPa
• Vapor pressure: 0.32 hPa ( 20 °C)

Properties

• Product Name: 1-Methyl-2-pyrrolidone, OmniSolv^®
• vapor pressure: 0.32 hPa ( 20 °C)
• Quality Segment: 100
• product line: OmniSolv^®
• assay: ≥99.7% (GC)
• form: liquid
• technique(s): HPLC: suitable, LC/MS: suitable, gas chromatography (GC): suitable
• impurities: ≤0.08% Water (H₂O), ≤1 μeq/g Titrable base
• ign. residue: ≤5 ppm
• color: APHA: ≤10
• pH: 8.5-10.0 (20 °C, 100 g/L in H₂O)
• bp: 202 °C/1013 hPa
• mp: -24 °C
• transition temp: flash point 91 °C
• solubility: 1000 g/L
• density: 1.03 g/cm³ at 20 °C
• UV cutoff: ≤270 nm
• UV absorption: λ: 270 nm A_max: ≤1.00, λ: 300 nm A_max: ≤0.20, λ: 325 nm A_max: ≤0.10, λ: 350 nm A_max: ≤0.03, λ: 400 nm A_max: ≤0.005
• shipped in: ambient
• storage temp.: room temp
• SMILES string: N1(CCCC1=O)C
• InChI: 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
• InChI key: SECXISVLQFMRJM-UHFFFAOYSA-N

Description

General description

NMP, also known as N-Methyl-2-pyrrolidone, is a versatile, water-miscible solvent widely recognized for its ability to improve the solubility and permeability of a broad range of pharmaceutical compounds. Its high thermal stability with a boiling point of 202 °C is well-suited for formulations that require heat sterilization. These properties make it a reliable and effective solubilizing agent for pharmaceutical development.

Application

NMP may be used as a solvent

• in a modified Fmoc-deprotection during solid-phase peptide synthesis for the reduction of diketopiperazine formation.
• in gel permeation chromatography (GPC) or size-exclusion chromatography (SEC) for analyzing high-molecular-weight polymers

OmniSolv^®

Packaging

M-Bottle for Solvents
As a global leader in lab reagents, we are constantly looking for new ways to optimize the safety of our products. The newly developed 4L solvent bottle design features advanced sealing technology that eliminates leaks to make the handling of solvents safer and more convenient than ever before.
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is packaged in 4L amber glass bottle

Preparation Note

Product filtered through a 0.2 μm filter

Analysis Note

Assay (GC)99.7% minColor (APHA)10 maxFiltered through 0.2 µm filterTo pass testFormClear liquidInfrared SpectrumConforms to standardResidue after ignition5ppm maxTitrable base1µeq/g maxUV Abs. at 270 nm1.00AU maxUV Abs. at 300 nm0.20AU maxUV Abs. at 325 nm0.10AU maxUV Abs. at 350 nm0.03AU maxUV Abs. at 400 nm0.005AU maxUV Cut-off270nm maxWater (H2O)0.08% max

Legal Information

OMNISOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Codes: H315,H319,H335,H360D
• Precautionary Statements: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flash Point (°F): 195.8 °F - Pensky-Martens closed cup
• Flash Point (°C): 91 °C - Pensky-Martens closed cup