EZHPI

Human Proinsulin ELISA Kit

Name: Human Proinsulin ELISA Kit
Brand: MM
Price: 77690 INR
Availability: InStock

measures and quantifies Proinsulin levels in 20 μL serum or plasma

Synonym(s):

Human Proinsulin Detection, Proinsulin ELISA

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96 WELLS

₹77,690.00

Estimated to ship on15 January 2026Details

About This Item

UNSPSC Code:

12161503

eCl@ss:

32161000

NACRES:

NA.32

Key Documents

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Product Name

Human Total Proinsulin ELISA, This Human Total Proinsulin ELISA is used to measure & quantify Proinsulin levels in Metabolism & Endocrine & Cell Signaling research.

species reactivity

human

packaging

kit of 1 × 96 wells

parameter

20 μL sample volume (4hr assay)

assay range

accuracy: 88-103%
linearity: 84-120%
sensitivity: 0.5 pM
standard curve range: 2-200 pM

technique(s)

ELISA: suitable

input

sample type serum
sample type plasma (K2 EDTA)

NCBI accession no.

NM_000207.2

UniProt accession no.

P01308

application(s)

research use

detection method

colorimetric (450nm)

shipped in

wet ice

storage temp.

2-8°C

Quality Level

200

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This Item	EZHI	EZHGIP	EZHL
Millipore EZHPI Human Total Proinsulin ELISA	Millipore EZHI Human Insulin ELISA	Millipore EZHGIP Human GIP (total) ELISA	Millipore EZHL Human Leptin "Dual Range" ELISA
species reactivity human	species reactivity human	species reactivity human	species reactivity human
input sample type serum sample type plasma (K2 EDTA)	input sample type plasma (K2 EDTA) sample type serum sample type cell culture supernatant	input sample type cell culture supernatant sample type serum sample type plasma (K2 EDTA)	input sample type cell culture supernatant sample type plasma (K2 EDTA) sample type serum
assay range accuracy: 88-103%, sensitivity: 0.5 pM, linearity: 84-120%, standard curve range: 2-200 pM	assay range accuracy: 76-103%, linearity: 96-112%, standard curve range: 2-200 μU/mL	assay range accuracy: 86.7%, linearity: 99.9%, sensitivity: 8.2 pg/mL, standard curve range: 8.2-2000 pg/mL	assay range accuracy: 94-114%, intra-assay cv: 1.4-4.9 (Sensitive Assay), intra-assay cv: 2.6-4.6, linearity: 80-105%, linearity: 96-125% (sensitive assay), sensitivity: 0.125 ng/mL (sensitive assay), sensitivity: 0.125-20 ng/mL, sensitivity: 0.5 ng/mL, standard curve range: 0.5-100 ng/mL
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
detection method colorimetric (450nm)	detection method colorimetric (450nm)	detection method colorimetric (450nm/590nm)	detection method colorimetric (450nm/590nm)
technique(s) ELISA: suitable	technique(s) ELISA: suitable	technique(s) ELISA: suitable	technique(s) ELISA: suitable

Application

Human Total Proinsulin ELISA has been used to measure plasma, serum, eye, and retinal levels of human proinsulin.

Disclaimer

For research use only. Not for use in diagnostic procedures.

General description

Proinsulin, the precursor of insulin and C-peptide, is made by the β cells of the pancreas. Proinsulin formed by the cleavage of pre-proinsulin contains B- and A-domains linked through the connecting domain. Proinsulin interacts with insulin receptor-A (IR-A) isoform present in the nervous system and exhibits antiapoptotic and neuroprotective effects in the developing and postnatal nervous system. Elevated levels of proinsulin serve as a marker for secretory β-cell dysfunction. Increased levels of this hormone are also observed in patients with type 2 diabetes and impaired glucose tolerance. This kit measures the intact and intermediate metabolic forms of human proinsulin.

Other Notes

Research Sub Category
Obesity
Metabolic Disorders
Research Category
Metabolism
20 μL sample volume 3 hour assay, room temperature

pictograms

GHS05,GHS07

signalword

Warning

hcodes

H290,H317

pcodes

P234 - P261 - P272 - P280 - P302 + P352 - P333 + P313

Hazard Classifications

Met. Corr. 1 - Skin Sens. 1

Storage Class

8A - Combustible corrosive hazardous materials

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Proinsulin and the genetics of diabetes mellitus.

Michael A Weiss

The Journal of biological chemistry, 284(29), 19159-19163 (2009-04-28)

Insulin plays a central role in the regulation of vertebrate metabolism. The hormone, the post-translational product of a single-chain precursor, is a globular protein containing two chains, A (21 residues) and B (30 residues). Recent advances in human genetics have

Intravitreal Injection of Proinsulin-Loaded Microspheres Delays Photoreceptor Cell Death and Vision Loss in the rd10 Mouse Model of Retinitis Pigmentosa.

Carolina Isiegas et al.

Investigative ophthalmology & visual science, 57(8), 3610-3618 (2016-07-09)

The induction of proinsulin expression by transgenesis or intramuscular gene therapy has been shown previously to retard retinal degeneration in mouse and rat models of retinitis pigmentosa (RP), a group of inherited conditions that result in visual impairment. We investigated

The Prohormone Proinsulin as a Neuroprotective Factor: Past History and Future Prospects.

Flora de Pablo et al.

Frontiers in molecular neuroscience, 11, 426-426 (2018-12-12)

Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to be isolated and sequenced. While its role as an insulin precursor has been extensively studied

Elevated intact proinsulin levels are indicative of Beta-cell dysfunction, insulin resistance, and cardiovascular risk: impact of the antidiabetic agent pioglitazone.

Andreas Pfützner et al.

Journal of diabetes science and technology, 5(3), 784-793 (2011-07-05)

Insulin resistance (IR) and deterioration of beta-cell secretion are main features in the development of type 2 diabetes, which is reflected in increasing serum intact proinsulin levels in later disease stage. Introduction of stable assays that are able to distinguish

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa.

Alonso Sánchez-Cruz et al.

Cell death & disease, 13(4), 383-383 (2022-04-22)

Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the leading cause of inherited blindness, is a group of retinal dystrophies characterized by photoreceptor dysfunction and death. The insulin receptor

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