According to Section 7 of the SDS, the item should be stored at room temp.
P2116
Pirfenidone
≥97% (HPLC), powder, antifibrotic agent
Synonym(s):
5-Methyl-1-phenyl-2-(1H)-pyridone
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10 MG
₹15,035.93
50 MG
₹56,668.88
About This Item
Empirical Formula (Hill Notation):
C12H11NO
CAS Number:
Molecular Weight:
185.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Product Name
Pirfenidone, ≥97% (HPLC)
SMILES string
O=C(C=CC(C)=C1)N1C2=CC=CC=C2
InChI key
ISWRGOKTTBVCFA-UHFFFAOYSA-N
InChI
1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
assay
≥97% (HPLC)
form
powder
solubility
H2O: >10 mg/mL at 60 °C (warming for 30 minutes)
DMSO: >20 mg/mL
originator
Shionogi
Quality Level
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Related Categories
1 of 4
This Item | Y0001769 | L1920 | N0915 |
|---|---|---|---|
| assay ≥97% (HPLC) | assay - | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form - | form powder | form powder |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
| solubility H2O: >10 mg/mL at 60 °C (warming for 30 minutes), DMSO: >20 mg/mL | solubility - | solubility DMSO: >20 mg/mL | solubility DMSO: >20 mg/mL |
| originator Shionogi | originator - | originator Eli Lilly | originator - |
Application
Pirfenidone has been used:
- as a post-operative eye drop in rabbits to analyse its antifibrotic effect to improve glaucoma filtration surgery[1]
- as an anti-scarring agent to examine whether it affects the foreign body reaction after glaucoma drainage device (GDD) implantation in a rabbit[2]
- to test its antifibrotic potential in primary cultures of human orbital fibroblasts (hOFs)[3]
- as tumor necrosis factor (TNFα) inhibitor to study its effect in hypoxia[4]
Biochem/physiol Actions
Inhibits collagen production and fibroblast proliferation.
Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.
Features and Benefits
This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Huzaifa I Adamali et al.
Drug design, development and therapy, 6, 261-272 (2012-10-12)
Over the past decade, there has been a cohesive effort from patients, physicians, clinical and basic scientists, and the pharmaceutical industry to find definitive treatments for idiopathic pulmonary fibrosis (IPF). As understanding of disease behavior and pathogenesis has improved, the
Pirfenidone safety and adverse event management in idiopathic pulmonary fibrosis
Lancaster L H, et al.
European Respiratory Review, 26(146), 170057-170057 (2017)
Arata Azuma
Therapeutic advances in respiratory disease, 6(2), 107-114 (2012-02-16)
Pirfenidone is the first antifibrotic agent to be approved for the treatment of pulmonary fibrosis. Idiopathic pulmonary fibrosis (IPF) is one of the idiopathic interstitial pneumonias with the worst prognoses; approximately half of patients die within 3-5 years, and the
CX3CL1 (fractalkine) and TNF alpha production by perfused human placental lobules under normoxic and hypoxic conditions in vitro: the importance of CX3CR1 signaling
Szukiewicz D, et al.
Inflammation Research, 63(3), 179-189 (2014)
Evaluation of pirfenidone as a new postoperative antiscarring agent in experimental glaucoma surgery
Zhong H, et al.
Investigative Ophthalmology & Visual Science, 52(6), 3136-3142 (2011)
Articles
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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