SML2631

IITZ-01

Name: IITZ-01
Brand: SIGMA
Price: 7371.83 INR
Availability: InStock

≥98% (HPLC)

Synonym(s):

N2-[4-(1H-Bbenzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine

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5 MG

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25 MG

₹29,703.80

₹7,371.83

Estimated to ship on11 February 2026Details

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₃FN₈O

CAS Number:

1807988-47-1

Molecular Weight:

482.51

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD31746904

Key Documents

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Product Name

IITZ-01, ≥98% (HPLC)

SMILES string

Fc1ccc(cc1)Nc2nc(nc(n2)Nc4ccc(cc4)c5[nH]c6c(n5)cccc6)N3CCOCC3

InChI

1S/C26H23FN8O/c27-18-7-11-20(12-8-18)29-25-32-24(33-26(34-25)35-13-15-36-16-14-35)28-19-9-5-17(6-10-19)23-30-21-3-1-2-4-22(21)31-23/h1-12H,13-16H2,(H,30,31)(H2,28,29,32,33,34)

InChI key

XGEDDGLPNSLBFE-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Bioactive Small Molecule Inhibitors

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Show Differences

1 of 4

This Item	SML2621	SML2174	SML2393
Sigma-Aldrich SML2631 IITZ-01	Sigma-Aldrich SML2621 ZT-12-037-01	Sigma-Aldrich SML2174 MS012	Sigma-Aldrich SML2393 XL019
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level -	Quality Level -	Quality Level -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear (warmed)	solubility DMSO: 2 mg/mL
color white to beige	color white to beige	color white to beige	color white to beige

Biochem/physiol Actions

IITZ-01 is a cell penetrant and potent autophagy inhibitor in numerous cancer cells including breast, lung, and colon cancer cells. It significantly elevates LC3-II and SQSTM1 protein levels in starvation-induced autophagy conditions. IITZ-01 accumulates within lysosomes causing liposomal deacidification, impairment of lysosomal maturation and inhibition of lysosomal degradation. Additionally, IITZ-01 induces apoptosis through the mitochondria-mediated pathway in TNBC cells MDA-MB-231 and MDA-MB-453, while sparing normal mammary epithelial MCF10A cell.

cell penetrant and potent autophagy inhibitor in numerous cancer cells

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000096425

0000096426

0000085323

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Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents

Kumar GJ, Kumar SN, Thummuri D, Adari LBS, Naidu VGM, Srinivas K, Rao VJ

Medicinal Chemistry Research, 24, 3991-4001 (2015)

IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo.

Lalita Guntuku et al.

Oncogene, 38(4), 581-595 (2018-09-01)

Autophagy is a homeostatic process that recycles damaged organelles and long-lived proteins by delivering them in double-membrane vesicles to lysosomes for degradation. Autophagy has a prominent role in survival, proliferation, and resistance of tumors in metabolic and chemotherapeutic stress conditions.

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IITZ-01