A1028

8-Anilino-1-naphthalenesulfonic acid

Name: 8-Anilino-1-naphthalenesulfonic acid
Brand: SIAL

≥97% purity (HPLC), powder

Synonym(s):

N-Phenyl peri acid, ANS, ANSA

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About This Item

Linear Formula:

C₆H₅NHC₁₀H₆SO₃H

CAS Number:

82-76-8

Molecular Weight:

299.34

NACRES:

NA.47

PubChem Substance ID:

24890494

UNSPSC Code:

12171500

MDL number:

MFCD00003998

Beilstein/REAXYS Number:

1843887

Key Documents

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Product Name

8-Anilino-1-naphthalenesulfonic acid,

InChI

1S/C16H13NO3S/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13/h1-11,17H,(H,18,19,20)

SMILES string

OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12

InChI key

FWEOQOXTVHGIFQ-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

composition

, <0.5% (solvent)

color

black
gray to dark green

mp

215-217 °C (dec.) (lit.)

solubility

DMF: 50 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

200

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Show Differences

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This Item	D4645	10417	H1252
Sigma-Aldrich A1028 8-Anilino-1-naphthalenesulfonic acid	Sigma-Aldrich D4645 Sodium 3,5-dichloro-2-hydroxybenzenesulfonate	Sigma-Aldrich 10417 8-Anilino-1-naphthalenesulfonic acid ammonium salt	Sigma-Aldrich H1252 Homovanillic acid
color black, gray to dark green	color white to off-white	color -	color white to off-white
form powder	form powder	form solid	form powder
solubility DMF: 50 mg/mL	solubility H₂O: 50 mg/mL	solubility H₂O: 0.1 g/5mL, clear to very slightly hazy (hot), NaOH: 1 N, H₂O: soluble, acetone: soluble, methanol: soluble	solubility ethanol: 50 mg/mL, colorless to light yellow
application(s) diagnostic assay manufacturing hematology histology	application(s) diagnostic assay manufacturing hematology histology	application(s) -	application(s) diagnostic assay manufacturing hematology histology
storage temp. room temp	storage temp. room temp	storage temp. -	storage temp. room temp
assay ≥97% (HPLC)	assay ≥98% (TLC)	assay ≥97.0% (HPLC)	assay >99% (TLC)

Application

8-Anilino-1-naphthalenesulfonic acid (ANS) has been used to study the thermal aggregation of BSA (bovine serum albumin).[1][2]

Biochem/physiol Actions

8-Anilino-1-naphthalenesulfonic acid (ANS) is an important dye which is used to study the intermediate states in the folding/unfolding pathways of proteins. It is also useful to check the conformational changes involved with the aggregation of proteins. ANS is nonfluorescent in the aqueous solution, however, it fluoresces strongly upon binding to BSA (bovine serum albumin) and denatured proteins. It is used for the detection of albumin in the serum. ANS mainly interacts with the solvent exposed nonpolar (hydrophobic) sites.[3]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Uversky VN and Permiakov EA

Methods in Protein Structure and Stability Analysis (2007)

Thermal aggregation of glycated bovine serum albumin.

Rondeau P, et al.

Biochimica et Biophysica Acta, 1804, 789-789 (2010)

Stable and pH-sensitive protein nanogels made by self-assembly of heat denatured soy protein.

Nannan Chen et al.

Journal of agricultural and food chemistry, 62(39), 9553-9561 (2014-09-03)

In this study, we examined the possibility of preparing stable soy protein nanogels by simply heating homogeneous soy protein dispersion. The protein nanogels formed were characterized by z-average hydrodynamic diameter, polydispersity index, turbidity, ζ-potential, morphology, and their stability to pH

Thermal aggregation of bovine serum albumin at different pH: comparison with human serum albumin.

Vetri V, et al.

European Biophysics Journal, 36, 717-717 (2007)

Tourette syndrome deep brain stimulation: a review and updated recommendations.

Lauren E Schrock et al.

Movement disorders : official journal of the Movement Disorder Society, 30(4), 448-471 (2014-12-06)

Deep brain stimulation (DBS) may improve disabling tics in severely affected medication and behaviorally resistant Tourette syndrome (TS). Here we review all reported cases of TS DBS and provide updated recommendations for selection, assessment, and management of potential TS DBS

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