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Merck

C5735

L-Cystine

Synonym(s):

(R,R)-3,3′-Dithiobis(2-aminopropionic acid)

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MXP 4,987.00

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MXP 88,001.00

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MXP 161,780.00

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About This Item

Linear Formula:
[-SCH2CH(NH2)CO2H]2
CAS Number:
56-89-3
Molecular Weight:
240.30
Beilstein:
1728094
EC Number:
200-296-3
MDL number:
MFCD00064228
UNSPSC Code:
12352209
NACRES:
NA.26

Key Documents

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biological source

non-animal source

Assay

≥98.5%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

mp

>240 °C (dec.) (lit.)

solubility

1 M HCl: 100 mg/mL

suitability

suitable for manufacturing use

application(s)

pharmaceutical (small molecule)

SMILES string

N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O

InChI

1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1

InChI key

LEVWYRKDKASIDU-IMJSIDKUSA-N

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This Item
49603779539C8755
L-Cystine

SAFC

C5735

L-Cystine

L-Cystine certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

49603

L-Cystine

L-Cystine Wacker Chemie AG, ≥98.5%

Sigma-Aldrich

779539

L-Cystine

L-Cystine ≥98% (TLC), crystalline

Sigma-Aldrich

C8755

L-Cystine

form

powder

form

-

form

powder

form

crystalline

biological source

non-animal source

biological source

-

biological source

-

biological source

-

impurities

endotoxin, tested

impurities

-

impurities

≤0.02% ammonium, ≤0.2% ninhidrin positive substances (each), ≤10 ppm heavy metals

impurities

-

assay

≥98.5%

assay

-

assay

≥98.5%

assay

≥98% (TLC)

suitability

suitable for manufacturing use

suitability

-

suitability

-

suitability

-

application(s)

pharmaceutical (small molecule)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

-

application(s)

cell analysis
peptide synthesis

General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
CDBG8525
CDBG8524
CDBG8061
CDBG8060
CDBG8062

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Anne C Conibear et al.
The Journal of biological chemistry, 288(15), 10830-10840 (2013-02-23)
θ-Defensins are ribosomally synthesized cyclic peptides found in the leukocytes of some primate species and have promising applications as antimicrobial agents and scaffolds for peptide drugs. The cyclic cystine ladder motif, comprising a cyclic peptide backbone and three parallel disulfide
Jan Lewerenz et al.
Antioxidants & redox signaling, 18(5), 522-555 (2012-06-07)
The antiporter system x(c)(-) imports the amino acid cystine, the oxidized form of cysteine, into cells with a 1:1 counter-transport of glutamate. It is composed of a light chain, xCT, and a heavy chain, 4F2 heavy chain (4F2hc), and, thus
Maisie Lo et al.
Journal of cellular physiology, 215(3), 593-602 (2008-01-09)
The x(c) (-) cystine/glutamate antiporter is a major plasma membrane transporter for the cellular uptake of cystine in exchange for intracellular glutamate. Its main functions in the body are mediation of cellular cystine uptake for synthesis of glutathione essential for
Richard Bridges et al.
Pharmacological reviews, 64(3), 780-802 (2012-07-05)
System x(c)(-) represents an intriguing target in attempts to understand the pathological states of the central nervous system. Also called a cystine-glutamate antiporter, system x(c)(-) typically functions by exchanging one molecule of extracellular cystine for one molecule of intracellular glutamate.
Masa Cemazar et al.
Antioxidants & redox signaling, 10(1), 103-111 (2007-10-27)
Cyclic cystine knot proteins are small but topologically complex molecules that occur naturally in plants and have a wide range of bioactivities that make them interesting from a pharmaceutical perspective. Their remarkable stability is dependent on the correct formation of
View All Related Papers

Articles

L-Cysteine in Cell Culture

Importance and uses of cysteine in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

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