O9504

Oxaloacetic acid

Name: Oxaloacetic acid
Brand: SIGMA
Price: 3973 MXP

powder, suitable for hybridoma

Synonym(s):

2-Oxosuccinic acid, Ketosuccinic acid, Oxalacetic acid, Oxobutanedioic acid

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5 G

MXP 3,973.00

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About This Item

Linear Formula:

HOOCCH₂COCOOH

CAS Number:

328-42-7

Molecular Weight:

132.07

UNSPSC Code:

12352205

NACRES:

NA.75

PubChem Substance ID:

24898071

EC Number:

206-329-8

Beilstein/REAXYS Number:

1705475

MDL number:

MFCD00002592

Key Documents

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Product Name

Oxaloacetic acid, powder, suitable for hybridoma

InChI key

KHPXUQMNIQBQEV-UHFFFAOYSA-N

InChI

1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)

SMILES string

OC(=O)CC(=O)C(O)=O

assay

≥97% (HPLC)

form

powder

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

solubility

H₂O: 100 mg/mL

storage temp.

−20°C

Quality Level

200

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This Item	O7753	O4126	P3662
Sigma-Aldrich O9504 Oxaloacetic acid	Sigma-Aldrich O7753 Oxaloacetic acid	Sigma-Aldrich O4126 Oxaloacetic acid	Sigma-Aldrich P3662 Sodium pyruvate
assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥99%
technique(s) cell culture \| hybridoma: suitable	technique(s) cell culture \| insect: suitable, cell culture \| mammalian: suitable	technique(s) -	technique(s) cell culture \| hybridoma: suitable
solubility H₂O: 100 mg/mL	solubility H₂O: 100 mg/mL	solubility H₂O: 100 mg/mL, clear to slightly hazy, colorless to light yellow	solubility H₂O: 100 mg/mL
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C

Application

Use as a TCA (Krebs cycle) intermediate supplement in hybridoma cell culture applications. Enhances hybridoma growth and productivity.

related product

Product No.

Description

Pricing

O7753

Oxaloacetic acid, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97% (HPLC)

pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

0000501417

0000366662

0000308464

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Oxaloacetate: a novel neuroprotective for acute ischemic stroke.

Francisco Campos et al.

The international journal of biochemistry & cell biology, 44(2), 262-265 (2011-11-17)

It is well established that glutamate acts as an important mediator of neuronal degeneration during cerebral ischemia. Different kind of glutamate antagonists have been used to reduce the deleterious effects of glutamate. However, their preclinical success failed to translate into

Use of 14CO2 in estimating rates of hepatic gluconeogenesis.

E Esenmo et al.

The American journal of physiology, 263(1 Pt 1), E36-E41 (1992-07-01)

Estimating the rate of hepatic gluconeogenesis in vivo from the incorporation of 14C from 14CO2 into glucose requires determination of the rates in liver of equilibration of oxaloacetate with fumarate, conversion of oxaloacetate to phosphoenolpyruvate (PEP), and conversion of PEP

Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation.

Eva Brekke et al.

Glia, 60(1), 147-158 (2011-11-05)

Pyruvate carboxylation (PC) is thought to be the major anaplerotic reaction for the tricarboxylic acid cycle and is necessary for de novo synthesis of amino acid neurotransmitters. In the brain, the main enzyme involved is pyruvate carboxylase, which is predominantly

[Pyruvate dehydrogenase deficiency in a child with persistent lactic acidosis].

E Dworzak et al.

Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 23(6), 323-329 (1985-06-01)

Evidence is presented for defective pyruvate dehydrogenase (EC 4.1.1.1) in leukocytes and muscle tissue from a 10-year old child with persistent lactic acidosis, suffering from myasthenia and growth retardation. The defect is expressed in vitro by a depressed stimulation of

Activation and inhibition of pyruvate carboxylase from Rhizobium etli.

Tonya N Zeczycki et al.

Biochemistry, 50(45), 9694-9707 (2011-10-01)

While crystallographic structures of the R. etli pyruvate carboxylase (PC) holoenzyme revealed the location and probable positioning of the essential activator, Mg(2+), and nonessential activator, acetyl-CoA, an understanding of how they affect catalysis remains unclear. The current steady-state kinetic investigation

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