Vanadium and the cardiovascular functions.

Canadian journal of physiology and pharmacology (2004-12-02)
Lise Coderre, Ashok K Srivastava
RESUMEN

Inorganic and organic compounds of vanadium have been shown to exhibit a large range of insulinomimetic effects in the cardiovascular system, including stimulation of glucose transporter 4 (GLUT-4) translocation and glucose transport in adult cardiomyocytes. Furthermore, administration of vanadium compounds improves cardiac performance and smooth muscle contractility, and modulates blood pressure in various models of hypertension and insulin resistance. Vanadium compounds are potent inhibitors of protein tyrosine phosphatases. As a result, they promote an increase in protein tyrosine phosphorylation of several key components of the insulin signaling pathway, leading to the upregulation of phosphatidylinositol 3-kinase and protein kinase B, two enzymes involved in mediating GLUT-4 trans location and glucose transport. In addition, vanadium has also been shown to activate p38 mitogen-activated protein kinase and increase Ca2+ levels in several cell types. The ability of vanadium compounds to activate these signaling events may be responsible for their ability to modulate cardiovascular functions.

MATERIALES
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Sigma-Aldrich
Vanadium, powder, −325 mesh, 99.5% trace metals basis
Sigma-Aldrich
Vanadium, powder, -100 mesh, 99.9% trace metals basis
Sigma-Aldrich
Vanadium, foil, thickness 0.127 mm, 99.7% trace metals basis
Sigma-Aldrich
Vanadium, pieces, 1-3 mm, 99.9% trace metals basis
Sigma-Aldrich
Vanadium, foil, thickness 0.25 mm, 99.7% trace metals basis
Sigma-Aldrich
Vanadium, rod, diam. 6.2 mm, 99.7% trace metals basis
Vanadium, wire reel, 5m, diameter 0.5mm, as drawn, 99.8%
Vanadium, microfoil, disks, 10mm, thinness 0.1μm, specific density 60.8μg/cm2, permanent mylar 3.5μm support, 99.8+%
Vanadium, microfoil, disks, 10mm, thinness 0.25μm, specific density 140.4μg/cm2, permanent mylar 3.5μm support, 99.8+%
Vanadium, microfoil, disks, 10mm, thinness 1.0μm, specific density 611μg/cm2, permanent mylar 3.5μm support, 99.8+%
Vanadium, microfoil, disks, 25mm, thinness 0.1μm, specific density 60.8μg/cm2, permanent mylar 3.5μm support, 99.8+%
Vanadium, microfoil, disks, 25mm, thinness 0.25μm, specific density 140.4μg/cm2, permanent mylar 3.5μm support, 99.8+%
Vanadium, microfoil, disks, 25mm, thinness 1.0μm, specific density 611μg/cm2, permanent mylar 3.5μm support, 99.8+%
Vanadium, wire reel, 0.2m, diameter 0.1mm, as drawn, 99.8%
Vanadium, wire reel, 0.2m, diameter 0.25mm, hard, 99.8%
Vanadium, wire reel, 0.2m, diameter 0.5mm, as drawn, 99.8%
Vanadium, wire reel, 0.2m, diameter 1.0mm, Stress relieved, 99.8%
Vanadium, wire reel, 0.5m, diameter 0.1mm, as drawn, 99.8%
Vanadium, wire reel, 0.5m, diameter 0.25mm, hard, 99.8%
Vanadium, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.8%
Vanadium, wire reel, 0.5m, diameter 1.0mm, Stress relieved, 99.8%
Vanadium, wire reel, 1m, diameter 0.1mm, as drawn, 99.8%
Vanadium, wire reel, 1m, diameter 0.25mm, hard, 99.8%
Vanadium, wire reel, 1m, diameter 0.5mm, as drawn, 99.8%
Vanadium, wire reel, 1m, diameter 1.0mm, Stress relieved, 99.8%
Vanadium, wire reel, 2m, diameter 0.1mm, as drawn, 99.8%
Vanadium, wire reel, 2m, diameter 0.25mm, hard, 99.8%
Vanadium, wire reel, 2m, diameter 0.5mm, as drawn, 99.8%
Vanadium, wire reel, 2m, diameter 1.0mm, Stress relieved, 99.8%
Vanadium, wire reel, 5m, diameter 0.1mm, as drawn, 99.8%

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