The rise of metal radionuclides in medical imaging: copper-64, zirconium-89 and yttrium-86.

Future medicinal chemistry (2011-04-30)
Oluwatayo F Ikotun, Suzanne E Lapi
RESUMEN

Positron emission tomography, with its high sensitivity and resolution, is growing rapidly as an imaging technology for the diagnosis of many disease states. The success of this modality is reliant on instrumentation and the development of effective and novel targeted probes. Initially, research in this area was focused on what we will define in this article as 'standard' PET isotopes (carbon-11, nitrogen-13, oxygen-15 and fluorine-18), but the short half-lives of these isotopes limit radiopharmaceutical development to those that probe rapid biological processes. To overcome these limitations, there has been a rise in nonstandard isotope probe development in recent years. This review focuses on the biological probes and processes that have been examined, in additiom to the preclinical and clinical findings with nonstandard radiometals: copper-64, zirconium-89, and yttrium-86.

MATERIALES
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Sigma-Aldrich
Zirconium, powder, −100 mesh
Sigma-Aldrich
Zirconium, foil, thickness 0.1 mm, 99.98% trace metals basis
Sigma-Aldrich
Zirconium, sponge, ≥99% trace metals basis
Sigma-Aldrich
Zirconium, rod, diam. 6.35 mm, ≥99% trace metals basis
Zirconium, rod, 100mm, diameter 50mm, centerless ground, 99.2%
Sigma-Aldrich
Zirconium, powder, in water, -325 mesh, 99.5% trace metals basis (excluding Hf)
Zirconium, foil, not light tested, 50x50mm, thickness 0.006mm, 99.2%
Zirconium, rod, 1000mm, diameter 1.5mm, 99.2%
Zirconium, rod, 1000mm, diameter 12.7mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 2.0mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 3.0mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 5.0mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 6.0mm, centerless ground, 99.2%
Zirconium, rod, 1000mm, diameter 9.5mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 1.5mm, 99.2%
Zirconium, rod, 100mm, diameter 12.7mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 19.0mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 2.0mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 3.0mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 5.0mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 6.0mm, centerless ground, 99.2%
Zirconium, rod, 100mm, diameter 9.5mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 1.5mm, 99.2%
Zirconium, rod, 200mm, diameter 12.7mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 19.0mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 2.0mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 3.0mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 5.0mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 6.0mm, centerless ground, 99.2%
Zirconium, rod, 200mm, diameter 9.5mm, centerless ground, 99.2%

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