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Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)
George Psomas, Dimitris P Kessissoglou
ABSTRACT

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Raney®-Nickel, W.R. Grace and Co. Raney® 2800, slurry, in H2O, active catalyst
Sigma-Aldrich
Raney®-Nickel, W.R. Grace and Co. Raney® 2400, slurry, in H2O, active catalyst
Sigma-Aldrich
Raney®-Nickel, W.R. Grace and Co. Raney® 3202, slurry, in H2O, active catalyst
Sigma-Aldrich
Raney®-Nickel, W.R. Grace and Co. Raney® 4200, slurry, in H2O, active catalyst
Sigma-Aldrich
Nickel, powder, <1 μm, 99.8% trace metals basis
Sigma-Aldrich
Nickel, foil, thickness 0.25 mm, 99.995% trace metals basis
Sigma-Aldrich
Nickel, wire, diam. 0.25 mm, ≥99.9%
Sigma-Aldrich
Nickel, wire, diam. 0.5 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Nickel, foil, thickness 0.125 mm, ≥99.9%
Sigma-Aldrich
Nickel, powder, <150 μm, 99.99% trace metals basis
Nickel, foil, light tested, 50x50mm, thickness 0.0075mm, 99.95%
Nickel, rod, 500mm, diameter 1.5mm, 99.99+%
Nickel, rod, 200mm, diameter 2.0mm, annealed, 99%
Nickel, foil, 15mm disks, thickness 0.005mm, as rolled, 99.9%
Nickel, foil, 10mm disks, thickness 0.15mm, annealed, 99%
Nickel, foil, 10mm disks, thickness 0.125mm, annealed, 99%
Nickel, rod, 200mm, diameter 3.0mm, 99%
Nickel, foil, 15mm disks, thickness 0.0075mm, 99.9%
Nickel, rod, 100mm, diameter 40mm, 99%
Sigma-Aldrich
Nickel, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.95% trace metals basis
Nickel, foil, 50mm disks, thickness 0.20mm, annealed, 99%
Nickel, foil, 5m coil, thickness 0.0025mm, 99.95%
Nickel, foil, 50mm disks, thickness 0.003mm, 99.95%
Nickel, foil, 4mm disks, thickness 0.5mm, as rolled, 99.99+%
Nickel, foil, 50mm disks, thickness 0.05mm, annealed, 99.98%
Nickel, foil, 4mm disks, thickness 0.25mm, as rolled, 99.99+%
Nickel, foil, 50mm disks, thickness 0.05mm, 99.9%
Nickel, foil, 50mm disks, thickness 0.1mm, annealed, 99%
Nickel, foil, 50mm disks, thickness 0.5mm, as rolled, 99.99+%
Nickel, foil, 4mm disks, thickness 0.125mm, annealed, 99.98%