Merck

Fungal zinc metabolism and its connections to virulence.

Frontiers in cellular and infection microbiology (2013-10-18)
Charley C Staats, Lívia Kmetzsch, Augusto Schrank, Marilene H Vainstein
RESUMEN

Zinc is a ubiquitous metal in all life forms, as it is a structural component of the almost 10% of eukaryotic proteins, which are called zinc-binding proteins. In zinc-limiting conditions such as those found during infection, pathogenic fungi activate the expression of several systems to enhance the uptake of zinc. These systems include ZIP transporters (solute carrier 39 family) and secreted zincophores, which are proteins that are able to chelate zinc. The expression of some fungal zinc uptake systems are regulated by a master regulator (Zap1), first characterized in the yeast Saccharomyces cerevisiae. In this review, we highlight features of zinc uptake and metabolism in human fungal pathogens and aspects of the relationship between proper zinc metabolism and the expression of virulence factors and adaptation to the host habitat.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
Cinc, granular, 20-30 mesh, ACS reagent, ≥99.8%
Sigma-Aldrich
Cinc, dust, <10 μm, ≥98%
Sigma-Aldrich
Cinc, powder, <150 μm, 99.995% trace metals basis
Sigma-Aldrich
Cinc, purum, powder
Sigma-Aldrich
Cinc, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.9%, granular
Sigma-Aldrich
Cinc, granular, 30-100 mesh, 99%
Sigma-Aldrich
Cinc, foil, thickness 0.25 mm, 99.9% trace metals basis
Sigma-Aldrich
Cinc, nanopowder, 40-60 nm avg. part. size, ≥99% trace metals basis
Cinc, foil, 300x300mm, thickness 0.1mm, as rolled, 99.95+%
Sigma-Aldrich
Cinc, mossy, ≥99%
Sigma-Aldrich
Cinc, shot, <12 mm, 99.99% trace metals basis
Sigma-Aldrich
Zinc preparation, 5 g/dL Zn+2 in THF, highly reactive Rieke®metal
Sigma-Aldrich
Cinc, foil, thickness 1.0 mm, 99.99% trace metals basis
Sigma-Aldrich
Cinc, shot, 5 mm, 99.999% trace metals basis
Sigma-Aldrich
Cinc, sticks, diam. 7-10 mm, 99.97% trace metals basis
Cinc, wire reel, 5m, diameter 1.0mm, 99.99+%
Sigma-Aldrich
Cinc, foil, thickness 0.25 mm, 99.999% trace metals basis
Sigma-Aldrich
Cinc, pieces, 2-14 mesh, 99.9% trace metals basis
Sigma-Aldrich
Cinc, wire, diam. 1.0 mm, 99.995% trace metals basis
Cinc, wire reel, 5m, diameter 2.0mm, 99.99+%
Cinc, wire reel, 0.5m, diameter 1.0mm, 99.999%
Cinc, foil, 100x100mm, thickness 0.1mm, as rolled, 99.95+%
Cinc, foil, 300x300mm, thickness 0.35mm, as rolled, 99.95+%
Cinc, foil, 150x150mm, thickness 0.1mm, as rolled, 99.95+%
Cinc, foil, 25x25mm, thickness 3mm, as rolled, 99.99+%
Cinc, foil, 50x50mm, thickness 0.15mm, as rolled, 99.95+%
Cinc, wire reel, 1m, diameter 1.0mm, 99.99+%
Cinc, wire reel, 0.1m, diameter 1.0mm, 99.999%
Cinc, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%
Cinc, foil, 100x100mm, thickness 0.15mm, as rolled, 99.95+%