Roles of PPARs in health and disease.

Nature (2000-06-06)
S Kersten, B Desvergne, W Wahli
RESUMEN

In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in these diseases. This, together with the fact that PPAR activity can be modulated by drugs such as thiazolidinediones and fibrates, has instigated a huge research effort into PPARs. Here we present the latest developments in the PPAR field, with particular emphasis on the physiological function of PPARs during various nutritional states, and the possible role of PPARs in several chronic diseases.

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Sigma-Aldrich
Pioglitazone hydrochloride, ≥98% (HPLC)
Supelco
Pioglitazone hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
USP
Pioglitazone hydrochloride, United States Pharmacopeia (USP) Reference Standard
Pioglitazone hydrochloride, European Pharmacopoeia (EP) Reference Standard
Pioglitazone for system suitability, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
PPAR, α human, recombinant, expressed in E. coli, ≥75% (SDS-PAGE)
Sigma-Aldrich
PPAR, β human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Sigma-Aldrich
PPAR, γ human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Sigma-Aldrich
PPARα, ligand binding domain (170-468) human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Sigma-Aldrich
PPARβ, ligand binding domain (165-441) human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Sigma-Aldrich
PPARγ, ligand binding domain (165-441) human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Sigma-Aldrich
PPARα isotype, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Sigma-Aldrich
PPAR δ, ligand binding domain (165-441), GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Sigma-Aldrich
PPAR γ, ligand binding domain (204-477), GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

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