M9441
Microsomes from Liver, Pooled
from mouse(CD-1), male
Synonym(s):
lab equipment accessory
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biological source
mouse (CD-1)
Quality Level
form
liquid
packaging
vial of ~10 mg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
mouse ... Mgst1(56615)
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This Item | M9566 | M9191 | M0317 |
|---|---|---|---|
| Gene Information mouse ... Mgst1(56615) | Gene Information mouse ... Mgst1(56615) | Gene Information - | Gene Information - |
| biological source mouse (CD-1) | biological source mouse (CD-1) | biological source rat (Sprague-Dawley) | biological source human |
| form liquid | form liquid | form liquid | form - |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. - |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
General description
Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).[1]
Application
Microsomes from Liver, Pooled has been also been used to study the metabolic stability of antitumor agents[2] and tunicamycin.[3]
Microsomes from Liver, Pooled has been used in cell survival and mutation assays in Escherichia coli.[4]
Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomes might act as cell organelles and are actively involved in protein synthesis.[1] Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids.[5] Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.[6]
Source of drug metabolizing enzymes, including cytochrome P-450.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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AQ-4, a deuterium-containing molecule, acts as a microtubule-targeting agent for cancer treatment
Lin BY, et al.
European Journal of Pharmacology, 173093-173093 (2020)
Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design
Dong YY, et al.
Cell, 175(4), 1045-1058 (2018)
T Vu Nguyen et al.
ChemMedChem, 14(9), 927-937 (2019-03-06)
Tuberculosis (TB) remains a significant global health problem for which new therapeutic options are sorely needed. The ability of the causative agent, Mycobacterium tuberculosis, to reside within host macrophages and form biofilm-like communities contributes to the persistent and drug-tolerant nature
Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties.
Vavrikova E
International Journal of Molecular Sciences, 17(6) (2016)
Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes.
Lu AY and Coon MJ
The Journal of Biological Chemistry, 243(6), 1331-1332 (1968)
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