5.05484

SB-277011-A Dihydrochloride

• Synonym(s): SB-277011-A Dihydrochloride, SB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A
• Empirical Formula (Hill Notation): C₂₈H₃₀N₄O · 2HCl
• CAS Number: 1226917-67-4
• Molecular Weight: 511.49
• MDL number: MFCD16627999
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: water: 100 mM
• storage temp.: 2-8°C
• SMILES string: Cl.Cl.N4(CCc5c(ccc(c5)C#N)C4)CC[C@@H]1CC[C@H](CC1)NC(=O)c2c3c(ncc2)cccc3
• InChI: 1S/C28H30N4O.2ClH/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27;;/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33);2*1H/t20-,24-;;
• InChI key: HEZIOTGUXSPDAK-ONAIBGCWSA-N

Description

General description

A brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pK_i = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56.0 mg/kg and strong physiological response at 32.0 mg/kg.

Biochem/physiol Actions

Primary Target
D3

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Collins, G. T. et al. 2005. J. Pharmacol. Exp. Ther.314, 310.
Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther.294, 1154.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable