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Merck

C5VP001A

Cellicon® Filter Assembly with Durapore® Membrane

filtration area 0.01 m2

Synonym(s):

Cellicon® Perfusion Filter with Durapore® Membrane

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About This Item

UNSPSC Code:
42294704

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material

PET support
PVDF
polyester support

Quality Level

400

Agency

meets USP Biological Reactivity Test for class VI plastics (family component materials)

sterility

sterile; γ-irradiated (level of 25-40kGy)

flow rate measuring range

10 L/min (/m2)

parameter

1 psi max. reverse press. exposure at 25 °C
1-2.5 L process volume
15 psi at 25 °C (max. burst pressure)
5 psi max. inlet pressure at 25 °C

filtration area

0.01 m2

membrane filtration area

0.01 m2

pore size

5 μm pore size

storage temp.

15-25°C

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General description

Housing/Overmold/ Assembly fittings/Single-use pump head: Polypropylene; Feed screen: Polyethylene terephthalate (PET); Polyester; Tubing: AdvantaFlex (Thermoplastic Elastomer), DOW Pharma 65; Feed screen: Polyethylene terephthalate (PET); Polyester; Pressure sensors: Polysulfone; Cable ties: Nylon
The Cellicon® Perfusion Filter is designed to meet your perfused seed train challenges. It is a flat sheet cell retention filter running in tangential flow filtration mode part of a single-use assembly. Perfusion operations deliver high-density cell cultures that alleviate the burden of processing large production bioreactor volumes while increasing manufacturing flexibility. Introducing perfusion to your seed train makes it possible to inoculate a higher quantity of cells for one or more production bioreactors, thus increasing process efficiency.

Application

Microfiltration
Seed Train Perfusion

Features and Benefits

High throughput. Predictable linear scale up from lab to manufacturing scale. Reliable and reproducible performance. Low crossflow and cell shear.

Other Notes

These products are manufactured in a facility which adheres to Good Manufacturing Practices.

Legal Information

CELLICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Durapore is a registered trademark of Merck KGaA, Darmstadt, Germany

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Articles

Optimizing CHO Cells for Higher Productivity

Cellvento 4CHO-X Expansion Medium enhances cell biomass for bioreactor inoculation in cell expansion stages.

Operational and Financial Advantages of Cellicon® Cell Retention Solution in an N-1 Perfusion Process

This page describes the financial and operational advantages offered by the Cellicon® Cell Retention Device in an N-1 perfusion process at the 2,000 L scale in comparison to a cell retention device from another supplier.

Reproducible Scaling of a Cell Retention Filter Using the Cellicon® Cell Retention Solution

This page describes the design attributes of the Cellicon® filter assembly for cell retention and how they simplify scale-up of intensified upstream processes.

Scalability and Performance of Mobius® iFlex Bioreactors

This page summarizes several performance attributes and scalability data for Mobius® iFlex Bioreactors, single-use, stirred tank systems designed to support traditional and intensified fed-batch and perfusion cell culture applications.

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