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Merck

B1385

Butoxamine hydrochloride

analytical standard, for drug analysis, mixture of diastereomers

Synonym(s):

α-(1-[t-Butylamino]ethyl)-2,5-dimethoxybenzyl alcohol

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About This Item

Empirical Formula (Hill Notation):
C15H25NO3 · HCl
CAS Number:
Molecular Weight:
303.82
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

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Quality Level

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

Cl.COc1ccc(OC)c(c1)C(O)C(C)NC(C)(C)C

InChI

1S/C15H25NO3.ClH/c1-10(16-15(2,3)4)14(17)12-9-11(18-5)7-8-13(12)19-6;/h7-10,14,16-17H,1-6H3;1H

InChI key

URPAECSKKQLCII-UHFFFAOYSA-N

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This Item
A366994972B5274
technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable, solid phase extraction (SPE): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

format

neat

format

neat

format

neat

format

neat

Quality Level

200

Quality Level

-

Quality Level

100

Quality Level

100

grade

analytical standard, for drug analysis

grade

analytical standard

grade

analytical standard

grade

analytical standard, for drug analysis

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

General description

Butoxamine hydrochloride is a β-andrenoceptor antagonist, which shows β2-selectivity.[1][2]

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Nozomu Abe et al.
BioMed research international, 2020, 3214186-3214186 (2020-05-29)
Adrenaline quickly inhibits the release of histamine from mast cells. Besides β2-adrenergic receptors, several in vitro studies also indicate the involvement of α-adrenergic receptors in the process of exocytosis. Since exocytosis in mast cells can be detected electrophysiologically by the
Elena Grossini et al.
Endocrinology, 148(2), 806-812 (2006-11-18)
The peptide ghrelin has been linked to the atherosclerotic process and coronary artery disease. We planned to study, for the first time, the primary effects of ghrelin on the intact coronary circulation and determine the mechanisms involved. In 24 sodium
Alexander Zlotnik et al.
Journal of neurosurgical anesthesiology, 24(1), 30-38 (2011-10-08)
Isoflurane-anesthetized rats subjected to traumatic brain injury (TBI) show a transient reduction in blood L-glutamate levels. Having previously observed that isoproterenol produces a sustained decrease in blood glutamate levels in naive rats, we investigated the possible effects of nonselective and
Eloisa Pavesi et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 36(5), 926-939 (2011-01-07)
In the present work, we sought to mimic the internal state changes in response to a predator threat by pharmacologically stimulating the brain circuit involved in mediating predator fear responses, and explored whether this stimulation would be a valuable unconditioned
Nan Yang et al.
Respiratory research, 22(1), 65-65 (2021-02-25)
Airway inflammation is a key feature of chronic obstructive pulmonary disease (COPD) and inhaled corticosteroids (ICS) remain the main treatment for airway inflammation. Studies have noted the increased efficacy of ICS and long-acting beta 2 agonist (LABA) combination therapy in

Questions

  1. Can B1385 be used in mice?

    1 answer
    1. This product has not been tested for in vitro or in vivo use and is intended to be used as an analytical standard. While the material is not suitable for human or veterinary use, other researchers have used this item successfully in mouse models. See the link below to review a publication that may be of interest:
      https://pmc.ncbi.nlm.nih.gov/articles/PMC7867244/

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