This product has not been tested for use as an analytical standard. There are currently three products available that qualify for use as a standard, under the name Ubidecarenone - 2 primary standards and 1 secondary standard. Please see the link below to review these product options:
https://www.sigmaaldrich.com/US/en/substance/ubidecarenone86334303980
C9538
Coenzyme Q10
≥98% (HPLC), powder, antioxidant
Synonym(s):
CoQ10, Q-10, Ubiquinone 50, Ubiquinone-10
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About This Item
Empirical Formula (Hill Notation):
C59H90O4
CAS Number:
Molecular Weight:
863.34
Beilstein:
1900141
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Coenzyme Q10, ≥98% (HPLC)
Assay
≥98% (HPLC)
form
powder
color
yellow to dark orange
mp
49 °C
application(s)
cell analysis
storage temp.
−20°C
SMILES string
O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O
InChI
1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
InChI key
ACTIUHUUMQJHFO-UPTCCGCDSA-N
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This Item | U0020000 | 1705301 | 1705312 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| form powder | form solid | form - | form - |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| color yellow to dark orange | color - | color - | color - |
| mp 49 °C | mp 49 °C | mp - | mp - |
General description
Coenzyme Q (CoQ), also known as ubiquinone, is a lipid-soluble antioxidant and is an essential component of the mitochondrial electron transport chain. The molecule contains a biologically active quinone with a benzoquinone ring and an isoprenoid sidechain. Q10 is synthesized in the cytoplasm and mitochondria ([1]) which generates ATP through aerobic cellular respiration. CoQ10 is required for the optimal functioning of the immune system and for cardiovascular health ([2]). The ability to repress inflammatory gene expression exhibits its anti-inflammatory property ([3] ) Genetic failure or ageing results in CoQ10 deficiency, indicated by suppression of immune function. ([1])
Application
Biochem/physiol Actions
Coenzyme Q10 is an endogenous cellular antioxidant and an essential component of the electron transfer chain. CoQ10 takes part in aerobic cellular respiration and generation of energy in the form of ATP.[5]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Lionel Van Maldergem et al.
Annals of neurology, 52(6), 750-754 (2002-11-26)
A 31-year-old woman had encephalopathy, growth retardation, infantilism, ataxia, deafness, lactic acidosis, and increased signals of caudate and putamen on brain magnetic resonance imaging. Muscle biochemistry showed succinate:cytochrome c oxidoreductase (complex II-III) deficiency. Both clinical and biochemical abnormalities improved remarkably
Jan Aaseth et al.
Mechanisms of ageing and development, 197, 111521-111521 (2021-06-16)
Coenzyme Q10 (CoQ10) is an essential component of the mitochondrial electron transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All cells produce CoQ10 by a specialized cytoplasmatic-mitochondrial pathway. CoQ10 deficiency can result from genetic failure or
Steven Lunetta et al.
Journal of AOAC International, 91(4), 702-708 (2008-08-30)
An international collaborative study was conducted of a high-performance liquid chromatographic (HPLC)-UV method for the determination of coenzyme Q10 (CoQ10, ubidecarenone) in raw materials and dietary supplements. Ten collaborating laboratories determined the total CoQ10 content in 8 blind duplicate samples.
S Ogasahara et al.
Neurology, 35(3), 372-377 (1985-03-01)
In a patient with Kearns-Sayre syndrome, concentration of coenzyme Q10, a component of the mitochondrial electron transport system, was decreased in serum and in the mitochondrial fraction of skeletal muscle. Serum concentrations of lactate and pyruvate were abnormally high, especially
Francisco M Gutierrez-Mariscal et al.
Antioxidants (Basel, Switzerland), 10(6) (2021-07-03)
Coenzyme Q10 (CoQ10), which plays a key role in the electron transport chain by providing an adequate, efficient supply of energy, has another relevant function as an antioxidant, acting in mitochondria, other cell compartments, and plasma lipoproteins. CoQ10 deficiency is
Articles
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Regarding this product, C9538, can it be used as primary reference standard for the content determination of CoQ10?
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