C9873

CPTH2

Name: CPTH2
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone

Slide 1 of 1

Sign Into View Organizational & Contract Pricing

Select a Size

Pricing and availability is not currently available.

About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₄ClN₃S

CAS Number:

357649-93-5

Molecular Weight:

291.80

MDL number:

MFCD02307488

UNSPSC Code:

12352200

PubChem Substance ID:

329775211

NACRES:

NA.77

Key Documents

View All Documentation

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Clc1ccc(cc1)-c2csc(N\N=C3\CCCC3)n2

InChI

1S/C14H14ClN3S/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12/h5-9H,1-4H2,(H,16,18)

InChI key

YYTHPXHGWSAKIZ-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	SML1046	SML1524	D5919
Sigma-Aldrich C9873 CPTH2	Sigma-Aldrich SML1046 CHIR99021	Sigma-Aldrich SML1524 (+)-JQ1	Sigma-Aldrich D5919 Diacylglycerol Kinase Inhibitor I
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: >10 mg/mL	solubility DMSO: 2 mg/mL, clear (warmed)	solubility DMSO: 20 mg/mL, clear	solubility 0.1 M HCl: slightly soluble, 0.1 M NaOH: slightly soluble, DMSO: soluble, H₂O: insoluble, ethanol: soluble, ethyl acetate: soluble
color white to beige	color white to light brown	color white to beige	color pale yellow

General description

CPTH2 ((3-methylcyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone)) inhibits histone acetyltransferase functionality and reduces acetylation of histone H3 [1] and H4.[2] CPTH2 promotes apoptosis in lymphoma cell lines.[2] It may serve as an anticancer agent. CPTH2 inhibits α-tubulin acetylation and modulates autophagic pathway in human acute myeloid leukemia cell lines.[3]

Application

CPTH2 has been used for the inhibition of histone acetyltransferase in cortical cultures,[4] bud cells[5] and natural killer T cells (iNKT).[6]

Biochem/physiol Actions

CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network.

CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Epigenetic profiling reveals a developmental decrease in promoter accessibility during cortical maturation in vivo

Venkatesh I, et al.

Neuroepigenetics, 8, 19-26 (2016)

A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4?-chlorophenyl) thiazol-2-yl) hydrazone

Chimenti F, et al.

Journal of Medicinal Chemistry, 52(2), 530-536 (2008)

The lysine acetyltransferase GCN5 is required for iNKT cell development through EGR2 acetylation

Wang Y, et al.

Cell Reports, 20(3), 600-612 (2017)

The thiazole derivative CPTH6 impairs autophagy

Ragazzoni Y, et al.

Cell Death & Disease, 4(3), e524-e524 (2013)

CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells

Trisciuoglio D, et al.

Clinical Cancer Research, 18(2), 475-486 (2012)

View All Related Papers

Articles

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service