O0884
Monoclonal Anti-Oncostatin M antibody produced in mouse
clone 17001, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-OSM
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About This Item
Conjugate:
unconjugated
Clone:
17001, monoclonal
Application:
ELISA (i), Neutral, WB
Citations:
4
Pricing and availability is not currently available.
biological source
mouse
Quality Segment
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
17001, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
indirect ELISA: suitable, neutralization: suitable, western blot: suitable
isotype
IgG2a
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... OSM(5008)
General description
Oncostatin M (OSM) is a growth-regulating cytokine produced by the activated T lymphocytes and macrophages. It has a pivotal role in stimulating the production of IL-6 in cultured human endothelial cells. It also facilitates the LDL receptor expression and its uptake by hepatoma cells. Further, OSM can induce synovial fibroblast-like cells to produce urokinase type plasminogen activator. Monoclonal anti-Oncostatin M antibody can be used for neutralizing the biological activity of rhOSM on the human TF-1 cell line. Mouse anti-Oncostatin M antibody reacts specifically with recombinant human OSM. The product has shown no cross-reactivity with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.
Immunogen
recombinant human OSM expressed in Escherichia coli.
Application
Monoclonal anti-Oncostatin M antibody can be used in western blotting and capture ELISA.
Biochem/physiol Actions
The antibody neutralizes the biological activity of recombinant human OSM. Does not cross-react with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline (PBS) with 5% trehalose.
Preparation Note
Purified using protein A.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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