PZ0195

CYP3cide

Name: CYP3cide
Brand: SIGMA

≥98% (HPLC), cytochrome P4503A4 inhibitor, powder

Synonym(s):

1-Methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine, PF-04981517

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₃₂N₈

CAS Number:

1390637-82-7

Molecular Weight:

456.59

MDL number:

MFCD22417344

UNSPSC Code:

12161501

PubChem Substance ID:

329823769

NACRES:

NA.77

Key Documents

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Product Name

CYP3cide, ≥98% (HPLC)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >10 mg/mL (warmed)

storage temp.

room temp

SMILES string

Cc1ccc(cc1)-c2c(cnn2C)-c3nn(C)c4ncnc(N5CC[C@@H](C5)N6CCCCC6)c34

InChI

1S/C26H32N8/c1-18-7-9-19(10-8-18)24-21(15-29-31(24)2)23-22-25(32(3)30-23)27-17-28-26(22)34-14-11-20(16-34)33-12-5-4-6-13-33/h7-10,15,17,20H,4-6,11-14,16H2,1-3H3/t20-/m0/s1

InChI key

WDWIMDKOXZZYHH-FQEVSTJZSA-N

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This Item	PZ0357	PZ0300	PZ0379
Sigma-Aldrich PZ0195 CYP3cide	Sigma-Aldrich PZ0357 PF-06412562	Sigma-Aldrich PZ0300 PF-06764427	Sigma-Aldrich PZ0379 PF-04827736
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. room temp
solubility DMSO: >10 mg/mL (warmed)	solubility DMSO: 30 mg/mL, clear	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 2 mg/mL, clear
color white to beige	color white to beige	color white to beige	color white to beige

Biochem/physiol Actions

CYP3cide is a mechanism-based inhibitor of cytochrome P4503A4 that can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on drug metabolism. The IC₅₀ values for inhibition of Midazolam 1′-Hydroxylase activity of recombinant CYP3A4 and CYP3A5 by CYP3cide are 0.3 and 17 mM, respectively.

CYP3cide is a mechanism-based inhibitor of cytochrome P4503A4.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure.

Andrew Rowland et al.

British journal of clinical pharmacology, 85(1), 216-226 (2018-10-20)

Demonstrate the presence of cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) proteins and mRNAs in isolated human plasma exosomes and evaluate the capacity for exosome-derived biomarkers to characterize variability in CYP3A4 activity. The presence of CYP and UGT protein and mRNA

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