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Merck

T2528

Terbutaline hemisulfate salt

β-adrenoceptor agonist

Synonym(s):

2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol, 5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol hemisulfate salt

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About This Item

Linear Formula:
C12H19NO3 · 1/2H2SO4
CAS Number:
23031-32-5
Molecular Weight:
274.32
EC Number:
245-386-3
MDL number:
MFCD00079584
UNSPSC Code:
12352200
PubChem Substance ID:
24278729
NACRES:
NA.77

Key Documents

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Product Name

Terbutaline hemisulfate salt,

solubility

H2O: soluble 100 mg/mL, clear to slightly hazy, colorless to yellow

originator

Novartis

SMILES string

OS(O)(=O)=O.CC(C)(C)NCC(O)c1cc(O)cc(O)c1.CC(C)(C)NCC(O)c2cc(O)cc(O)c2

InChI

1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)

InChI key

KFVSLSTULZVNPG-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155)

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This Item
I3639B8684T0050000
Terbutaline hemisulfate salt

Sigma-Aldrich

T2528

Terbutaline hemisulfate salt

Isoetharine mesylate salt

Sigma-Aldrich

I3639

Isoetharine mesylate salt

Bambuterol hydrochloride >98% (HPLC), powder

Sigma-Aldrich

B8684

Bambuterol hydrochloride

Terbutaline sulfate European Pharmacopoeia (EP) Reference Standard

T0050000

Terbutaline sulfate

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

-

solubility

H2O: soluble 100 mg/mL, clear to slightly hazy, colorless to yellow

solubility

-

solubility

H2O: soluble ~33 mg/mL

solubility

-

originator

Novartis

originator

Sanofi Aventis

originator

AstraZeneca

originator

-

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155)

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155)

Gene Information

-

Gene Information

human ... ADRB2(154)

Application

Terbutaline hemisulfate has been used as a reference standard for the determination of β agonist residues in meat4. It has also been used as a standard for developing LC-MS-MS based techniques for the analysis of veterinary drugs5.

Biochem/physiol Actions

Terbutaline is a β-adrenoceptor agonist and is known to function as a bronchodilator. Studies have reported that terbutaline is potent inhibitor of premature labor6.

Features and Benefits

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Terbutaline hemisulfate salt dissolves in water at 100 mg/ml to yield a colorless to yellow, clear to slightly hazy solution.

used together

Product No.
Description
Pricing

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H361,H370

Hazard Classifications

Repr. 2 - STOT SE 1

Target Organs

Cardio-vascular system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN4064
BCCJ7739
BCCC7481
BCBV3715
BCBQ7406V

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K Törneke et al.
Journal of veterinary pharmacology and therapeutics, 21(5), 388-392 (1998-11-12)
Beta2-adrenoceptor agonists are used as bronchodilators in both humans and horses. Of these drugs, clenbuterol is the one most frequently used when treating chronic obstructive pulmonary disease in the horse, while salbutamol and terbutaline are used in the treatment of
J Elers et al.
International journal of sports medicine, 33(12), 1026-1033 (2012-07-12)
We examined urine and serum concentrations after therapeutic use of single and repetitive doses of inhaled and supratherapeutic oral use of terbutaline. We compared the concentrations in 10 asthmatics and 10 healthy subjects in an open-label, cross-over study with 2
Andrew H Travers et al.
The Cochrane database of systematic reviews, 12, CD010179-CD010179 (2012-12-14)
Inhaled beta-agonist therapy is central to the management of acute asthma. This review evaluates the benefit of an additional use of intravenous beta(2)-agonist agents. To determine the benefit of adding intravenous (IV) beta(2)-agonists to inhaled beta(2)-agonist therapy for acute asthma
Theodore A Slotkin et al.
Neurotoxicology and teratology, 36, 91-96 (2012-07-21)
Terbutaline, a β2-adrenoceptor agonist, is used off-label for long-term management of preterm labor; such use is associated with increased risk of neurodevelopmental disorders, including autism spectrum disorders. We explored the mechanisms underlying terbutaline's effects on development of peripheral sympathetic projections
S Akhtar et al.
Critical care medicine, 27(8), 1551-1556 (1999-09-02)
Intraparenchymal airways are involved in air flow regulation. Relaxation of intraparenchymal airways to volatile anesthetics varied by topographic location. This study was conducted to determine whether other bronchodilators (terbutaline, diltiazem, and aminophylline) relax bronchiolus to a greater degree than bronchus
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