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Merck

171468

Perfluorooctanoic acid

95%

Synonym(s):

Pentadecafluorooctanoic acid, PFOA, Perfluorocaprylic acid, Perfluorooctanoic acid

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About This Item

Linear Formula:
CF3(CF2)6COOH
CAS Number:
Molecular Weight:
414.07
UNSPSC Code:
12352211
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-397-9
Beilstein/REAXYS Number:
1809678
MDL number:

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Product Name

Perfluorooctanoic acid, 95%

InChI key

SNGREZUHAYWORS-UHFFFAOYSA-N

InChI

1S/C8HF15O2/c9-2(10,1(24)25)3(11,12)4(13,14)5(15,16)6(17,18)7(19,20)8(21,22)23/h(H,24,25)

SMILES string

OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

assay

95%

bp

189 °C/736 mmHg (lit.)

mp

55-56 °C (lit.)

Quality Level

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1 of 4

This Item
7726229090433824
assay

95%

assay

≥98.0% (NT)

assay

97%

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

mp

55-56 °C (lit.)

mp

-

mp

-

mp

55-56 °C (lit.)

bp

189 °C/736 mmHg (lit.)

bp

-

bp

129-130 °C/744 mmHg (lit.)

bp

189 °C/736 mmHg (lit.)

Application

PFOA, its salts and related substances are listed in Part A of Annex I of the Persistent Organic Pollutants (POPs) Regulation (EU) 2019/1021. It can only be used for Laboratory-scale research or as a reference standard

Derogations until 4 July 2025 are uses in
  • photolithography or etch processes in semiconductor manufacturing
  • photographic coatings applied to films
  • invasive and implantable medical devices
The use is further allowed in firefighting foams for Class B fires until 4 July 2025

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Lact. - Repr. 1B - Skin Corr. 1C - STOT RE 1

target_organs

Liver

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Certificates of Analysis (COA)

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Binding of perfluorooctanoic acid to rat and human plasma proteins.
Han X, et al.
Chemical Research in Toxicology, 16(6), 775-781 (2003)
Effects of perfluorooctanoic acid exposure during pregnancy in the mouse.
Lau C, et al.
Toxicological Sciences, 90(2), 510-518 (2006)
Perfluoroalkyl acids: a review of monitoring and toxicological findings
C Lau, et al.
Toxicological Sciences, 99, 366-394 (2007)
Yusun Zhou et al.
Scientific reports, 6, 38633-38633 (2016-12-15)
Using a novel magnetic nanocomposite as adsorbent, a convenient and effective magnetic solid-phase extraction (MSPE) procedure was established for selective separation and concentration of nine perfluorinated compounds (PFCs) in surface water sample. Then an ultra high-performance liquid chromatography-tandem mass spectrometry
Responses of the Liver to Perfluorinated Fatty Acids with Different Carbon Chain Length in Male and Female Mice:In Relation to Induction of Hepatomegaly, Peroxisomal ?-Oxidation and Microsomal 1-Acylglycerophosphocholine Acyltransferase
N Kudo, et al.
Biological & Pharmaceutical Bulletin, 29, 1952-1957 (2006)

Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. What are the recommendations for storing an aqueous solution of PFOA (container, temperature, etc.)?

    1 answer
    1. The solution stability for this product in aqueous solutions has not been evaluated. Solutions prepared in methanol, such as product 33603, are stored refrigerated and assigned a shelf life of 2 years.

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  4. What is the solubility of Heptadecafluorooctanesulfonic acid potassium salt product 77282 (CAS 2795-39-3)?

    1 answer
    1. The solubility for 77282 has not been validated, but the product should be soluble in methanol and slightly soluble (miscible) in water (with heating and sonication).

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