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ACOA-RO

Roche

Acetyl-Coenzyme A

85% (Enzymatic and Absorbance), 2% (lithium)

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Synonym(s):
Acetyl-Coenzyme A, acetyl-coa

description

Chemical Formula: C23H35N7O17P3SLi3

Quality Level

Assay

85% (Enzymatic and Absorbance)

form

solid

mol wt

Mr 809.6 (acetyl-CoA)
Mr 827.4 (acetyl-CoA-Li3)

packaging

pkg of 010 mg (10101893001)
pkg of 200 mg (11585371001)
pkg of 050 mg (10101907001)

manufacturer/tradename

Roche

concentration

2% (lithium)

storage temp.

2-8°C

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This Item
MAK039I938107-303
Acetyl-Coenzyme A 85% (Enzymatic and Absorbance), 2% (lithium)

Roche

ACOA-RO

Acetyl-Coenzyme A

form

solid

form

-

form

-

form

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

description

Chemical Formula: C23H35N7O17P3SLi3

description

-

description

-

description

-

mol wt

Mr 809.6 (acetyl-CoA)

mol wt

-

mol wt

-

mol wt

-

General description

Acetyl-Coenzyme A, trilithium salt

Application

Acetyl-Coenzyme A is used to assay CAT enzyme activity in cell extracts using radioisotopes. CAT enzyme activity in cell extracts catalyzes the transfer of acetyl groups from acetylcoenzyme A to chloramphenicol. A number of assays have been developed to measure CAT activity in cell extracts. Acetyl-Coenzyme A has also been used to determine citrate synthase activity.

Biochem/physiol Actions

Acetyl-Coenzyme A (Ac-CoA) is the end product of glycolysis and takes part in the Ac-CoA pathway, which is a metabolic pathway for carbon compounds. Ac-CoA is important in cholesterol synthesis. It also takes part in fatty acid biosynthesis and catabolism of polyamines like spermine and spermidine. A low level of Ac-CoA leads to a loss in glial cell and neuronal function. Ketone bodies and triglycerides give rise to Ac-CoA on hydrolysis and this indirectly leads to increased histone acetylation.

Preparation Note

Working solution: Optimal solvent: water or aqueous solution with a weak acidic pH (4 to 5).
Storage conditions (working solution): -15 to -25 °C
50 mg/ml in phosphate buffer, pH 7, is stable for 3 weeks at -15 to -25 °C. Unfrozen solutions should be immediately used.

Other Notes

For life science research only. Not for use in diagnostic procedures.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Biochemistry null
L Lu et al.
The Journal of biological chemistry, 271(31), 18920-18924 (1996-08-02)
Polyamine catabolism is rate limited by spermidine/spermine N1-acetyltransferase (SSAT). Although the amino acid sequence of SSAT is known, the substrate binding and catalytic sites are not. The goal of this study was to define the region responsible for acetyl coenzyme
Morten Scheibye-Knudsen et al.
Cell metabolism, 20(5), 840-855 (2014-12-03)
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in genes encoding the DNA repair proteins CS group A or B (CSA or CSB). Since dietary interventions can alter neurodegenerative processes, Csb(m/m) mice were
Giosalba Burgio et al.
Biochimica et biophysica acta, 1799(10-12), 671-680 (2010-05-25)
The eukaryotic genome is a highly organized nucleoprotein structure comprising of DNA, histones, non-histone proteins, and RNAs, referred to as chromatin. The chromatin exists as a dynamic entity, shuttling between the open and closed forms at specific nuclear regions and
Agnieszka Jankowska-Kulawy et al.
Neurochemistry international, 57(7), 851-856 (2010-09-21)
Several pathologic conditions are known to cause thiamine deficiency, which induce energy shortages in all tissues, due to impairment of pyruvate decarboxylation. Brain is particularly susceptible to these conditions due to its high rate of glucose to pyruvate-driven energy metabolism.

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