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Merck

A8199

N-Acetyl-L-cysteine

≥99% (TLC), suitable for cell culture, BioXtra

Synonym(s):

LNAC, NAC

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10 G

PLN 745.00

100 G

PLN 2,133.50

1 KG

PLN 10,630.00

PLN 745.00


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About This Item

Linear Formula:
HSCH2CH(NHCOCH3)CO2H
CAS Number:
Molecular Weight:
163.19
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
210-498-3
MDL number:
Beilstein/REAXYS Number:
1724426

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Product Name

N-Acetyl-L-cysteine, BioXtra, ≥99% (TLC)

InChI key

PWKSKIMOESPYIA-BYPYZUCNSA-N

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

SMILES string

CC(=O)N[C@@H](CS)C(O)=O

product line

BioXtra

assay

≥99% (TLC)

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

≤0.002% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.5%

color

white to off-white

mp

106-108 °C (lit.)

solubility

H2O: 0.1 M at 20 °C, clear, colorless

cation traces

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.1%
Pb: ≤0.001%
Zn: ≤0.0005%

application(s)

cell analysis

storage temp.

2-8°C

Quality Level

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Show Differences

1 of 4

This Item
A7250A91651.12422
form

powder

form

powder

form

powder

form

solid

assay

≥99% (TLC)

assay

≥99% (TLC)

assay

≥99% (TLC)

assay

-

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

technique(s)

-

product line

BioXtra

product line

-

product line

BioReagent

product line

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-30°C

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

100

Application

N-Acetyl-L-cysteine has been used to study its protective effect against styrene-induced cochlear injuries in rats.[1] It has also been used as a supplement in basal chemically-defined medium (BDM) for the culture of oligodendrocyte precursor cells.[2]

Biochem/physiol Actions

Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination
Chen Y
PLoS ONE, 12(12), e0189380-e0189380 (2017)
Protective effect of N-acety-L-cysteine (L-NAC) against styrene-induced cochlear injuries
Wei Ping Yang
Acta Oto-Laryngologica, 129(10), 1036-1043 (2009)
Suzanne M Cloonan et al.
Journal of medicinal chemistry, 58(11), 4494-4505 (2015-05-12)
Ruthenium polypyridyl complexes show great promise as new photodynamic therapy (PDT) agents. However, a lack of detailed understanding of their mode of action in cells poses a challenge to their development. We have designed a new Ru(II) PDT candidate that
Michael Berk et al.
Trends in pharmacological sciences, 34(3), 167-177 (2013-02-02)
N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant glutathione, neurotrophins, apoptosis, mitochondrial function, and inflammatory pathways. This review summarises the areas where the mechanisms of action of
Yuval Samuni et al.
Biochimica et biophysica acta, 1830(8), 4117-4129 (2013-04-27)
N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion cardiac injury, acute respiratory distress syndrome, bronchitis, chemotherapy-induced toxicity

Articles

Znaczenie i zastosowanie cysteiny w hodowlach eukariotycznych bez surowicy, w tym hybrydoma i komórki jajnika chomika chińskiego (CHO)

Importance and uses of cysteine in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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