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Collagen Mimetic peptides MAPTRIX-C-TAIPSCPEGTVPLYS

Name: Collagen Mimetic peptides MAPTRIX-C-TAIPSCPEGTVPLYS
Brand: SIGMA

animal-free ECM peptides, solution, 0.5 mg/mL protein, suitable for cell culture

Synonym(s):

MAPTrix^™ Technology

About This Item

UNSPSC Code:

12352202

NACRES:

NA.75

Form:

aqueous solution

Technique(s):

cell culture | mammalian: suitable

Concentration:

0.5 mg/mL protein

Mol wt:

~24.1 kDa

This product is discontinued. Contact Technical Servicefor assistance.

Product Name

MAPTRIX-C-TAIPSCPEGTVPLYS, Collagen Mimetic, aqueous solution

sterility

Filtered sterilized solution

form

aqueous solution

mol wt

~24.1 kDa

packaging

pkg of 2.5 mg

concentration

0.5 mg/mL protein

technique(s)

cell culture | mammalian: suitable

binding specificity

Domain: α3(IV) NC1
Binding Motif: TAIPSCPEGTVPLYS

shipped in

ambient

storage temp.

2-8°C

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This Item	166314K	162292K	164422K
Sigma-Aldrich 166312K MAPTRIX-C-TAIPSCPEGTVPLYS	Sigma-Aldrich 166314K MAPTRIX-C-TAIPSCPEGTVPLYS	Sigma-Aldrich 162292K MAPTRIX-L-TWYKIAFQRNRK	Sigma-Aldrich 164422K MAPTRIX-L-KAFDITYVRLKF
sterility Filtered sterilized solution	sterility Filtered sterilized solution	sterility Filtered sterilized solution	sterility Filtered sterilized solution
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
concentration 0.5 mg/mL protein	concentration 1.0 mg/mL protein	concentration 0.5 mg/mL protein	concentration 0.5 mg/mL protein
form aqueous solution	form aqueous solution	form aqueous solution	form aqueous solution
mol wt ~24.1 kDa	mol wt ~24.1 kDa	mol wt ~24.2 kDa	mol wt ~24.1 kDa
binding specificity Domain: α3(IV) NC1 Binding Motif: TAIPSCPEGTVPLYS	binding specificity Domain: α3(IV) NC1 Binding Motif: TAIPSCPEGTVPLYS	binding specificity Receptor: α6β1 Domain: α1 LG2 - AG32 Binding Motif: TWYKIAFQRNRK	binding specificity Receptor: αvβ3, α5β1 Domain: γ1 chain - C16 Binding Motif: KAFDITYVRLKF

Application

MAPTrix^™ Technology provides a true extracellular microenvironment (ECM) by presenting combinatorial peptide motifs. The ECM, defined by biochemical cues and physical cues, is a deciding factor in a wide range of cellular processes including cell adhesion, proliferation, differentiation, and expression of phenotype-specific functions.Currently existing technology offers simple and merely adequate environments that facilitate simple cell processes such as cellular adhesion.[1][2] The simple presentation of cell adhesion motifs is not optimal for controlling more integrated processes. Crosstalk among signaling pathways act synergistically to enhance cellular responses such as cell adhesion or proliferation.[3] A study showed that a combination of extracellular matrix derived peptides presented on a surface may enhance cell adhesion strength and focal adhesion assembly. The combinatorial presentation of ECM peptides on cell growth surfaces may also promote elevated proliferation rates of primary or stem cells.[4][5][6]

Features and Benefits

Biochemically-defined, animal-free cell culture surfaces designed to enhance cell performance
MAPTrix^™ produces a uniform ECM surface that provides a highly controlled 2D extracellular microenvironment for cell cultures and related applications
Adhesion properties of the mussel adhesive protein makes the coating reproducible & reliable

Legal Information

MAPTrix is a trademark of Kollodis Biosciences

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

12 - Non Combustible Liquids

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Signalling by adhesion receptors.

S J Fashena et al.

Nature cell biology, 2(12), E225-E229 (2001-01-09)

Over the past twenty years, intensive research has enabled us to identify components of specific signalling pathways downstream of an array of adhesion and growth-factor receptors. The first Gordon Research Conference on 'Signalling by Adhesion Receptors', which took place in

Mixed extracellular matrix ligands synergistically modulate integrin adhesion and signaling.

Catherine D Reyes et al.

Journal of cellular physiology, 217(2), 450-458 (2008-07-10)

Cell adhesion to extracellular matrix (ECM) components through cell-surface integrin receptors is essential to the formation, maintenance and repair of numerous tissues, and therefore represents a central theme in the design of bioactive materials that successfully interface with the body.

Characterization of integrin engagement during defined human embryonic stem cell culture.

Ying Meng et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(4), 1056-1065 (2009-11-26)

Human embryonic stem (hES) cells are pluripotent, capable of differentiating into any cell type of the body, and therefore have the ability to provide insights into mechanisms of human development and disease, as well as to provide a potentially unlimited

Integrin-mediated adhesion and stem-cell-niche interactions.

Stephanie J Ellis et al.

Cell and tissue research, 339(1), 121-130 (2009-07-10)

The regulation of stem cell behavior and maintenance typically involves the integration of both intrinsic and extrinsic cues. One such external cue, integrin-mediated cell adhesion to the extracellular matrix, plays an important part in regulating stem cell function and maintenance.

Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms.

Samuel Schmidt et al.

Cell and tissue research, 339(1), 83-92 (2009-11-19)

Adhesion and migration are integrated cell functions that build, maintain and remodel the multicellular organism. In migrating cells, integrins are the main transmembrane receptors that provide dynamic interactions between extracellular ligands and actin cytoskeleton and signalling machineries. In parallel to

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Global Trade Item Number

SKU	GTIN
166312K-2.5MG	04061838748898

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