A231

Arachidonyl trifluoromethyl ketone

oil, ≥97% (NMR)

• Synonym(s): 1,1,1-Trifluoromethyl-6,9,12,15-heieicosatetraen-2-one, AACOCF₃, Arach-CF₃
• Empirical Formula (Hill Notation): C₂₁H₃₁F₃O
• CAS Number: 149301-79-1
• Molecular Weight: 356.47
• NACRES: NA.77
• PubChem Substance ID: 24890647
• UNSPSC Code: 51111800
• MDL number: MFCD00236427

Properties

• Quality Segment: 100
• assay: ≥97% (NMR)
• form: oil
• storage condition: desiccated, protect from light, under inert gas
• color: yellow
• solubility: DMSO: >5 mg/mL
• storage temp.: −20°C
• SMILES string: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F
• InChI: 1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-
• InChI key: PLWROONZUDKYKG-DOFZRALJSA-N
• Gene Information: human ... PLA2G1B(5319)

Description

Application

Arachidonyl trifluoromethyl ketone (AACOCF3) has been used as a anandamide degradation inhibitor to study its effects in primary astrocyte cultures.

Biochem/physiol Actions

Arachidonyl trifluoromethyl ketone (AACOCF3) plays a role in the inhibition of 12-hydroxyeicosatetraenoic acid (12-HETE) and thromboxane B2 produced by the platelets.

Inhibits anandamide hydrolysis in vitro; inhibits phospholipase A₂.

Features and Benefits

This compound is featured on the Phospholipase A2 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Hygroscopic, photosensitive, air sensitive

Safety Information

• Storage Class: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)