B7005

Betamethasone

synthetic (organic), ≥98%, corticosteroid, powder

• Synonym(s): 9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16β-methylprednisolone
• Empirical Formula (Hill Notation): C₂₂H₂₉FO₅
• CAS Number: 378-44-9
• Molecular Weight: 392.46
• NACRES: NA.77
• PubChem Substance ID: 57653954
• UNSPSC Code: 51111800
• EC Number: 206-825-4
• MDL number: MFCD00062969
• eCl@ss: 32150313
• Assay: ≥98%
• Form: powder

Properties

• Product Name: Betamethasone, ≥98%
• biological source: synthetic (organic)
• Quality Segment: 100
• sterility: non-sterile
• assay: ≥98%
• form: powder
• mp: 235-237 °C (lit.)
• solubility: water: 0.063 g/L at 37 °C
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C
• InChI: 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
• InChI key: UREBDLICKHMUKA-DVTGEIKXSA-N
• Gene Information: human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908) ; mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Tnf(21926) ; rat ... Ar(24208), Nr3c1(24413), Tnf(24835) ;

Description

Application

Betamethasone has been used as a corticosteroid (CORT) standard.

Biochem/physiol Actions

Betamethasone, an isomer of dexamethasone is also termed as 9α-fluoro-16β-methyl-11 β,17,21-trihydroxypregna-1,4-dien-3,20-dione or 9α-fluoro-16β-methylprednisolone (27.1.52). It can be used as an anti-itch agent and treating dermatitis and eczema.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Codes: H360FD,H373
• Precautionary Statements: P201 - P202 - P260 - P280 - P308 + P313 - P405
• Hazard Classifications: Repr. 1B - STOT RE 2
• Target Organs: Liver,Kidney,Endocrine system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)