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Merck

C160

CGP-42112A

synthetic, ≥95%, Angiotensin II receptor antagonist, solid

Synonym(s):

Nα-Nicotinoyl-Tyr-(Nα-Cbz-Arg)-Lys-His-Pro-Ile

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1 MG

PLN 1,020.00

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PLN 3,646.50

PLN 1,020.00

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About This Item

Empirical Formula (Hill Notation):
C52H69N13O11
CAS Number:
127060-75-7
Molecular Weight:
1052.18
NACRES:
NA.77
PubChem Substance ID:
24892424
UNSPSC Code:
12352200
MDL number:
MFCD00133611
Beilstein/REAXYS Number:
8184948

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Product Name

CGP-42112A, ≥95%, synthetic, solid

assay

≥95%

form

solid

color

white

InChI key

UXGNARZDONUMMK-LRMQDCNJSA-N

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)c5cccnc5)C(O)=O

InChI

1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1

biological source

synthetic

storage temp.

−20°C

Quality Level

200

Gene Information

human ... AGTR2(186)
rat ... AGTR2(11609)

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Show Differences

1 of 4

This Item
S3672492042SML2988
CGP-42112A ≥95%, synthetic, solid

Sigma-Aldrich

C160

CGP-42112A

[Sar9, Met(O2)11]-Substance P ≥95% (HPLC)

Sigma-Aldrich

S3672

[Sar9, Met(O2)11]-Substance P

Nrf2 Activator III, TAT-14 Peptide The Nrf2 Activator III, TAT-14 Peptide modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Biochemicals applications.

Sigma-Aldrich

492042

Nrf2 Activator III, TAT-14 Peptide

Tat-NR2B9c trifluoroacetate ≥95% (HPLC)

Sigma-Aldrich

SML2988

Tat-NR2B9c trifluoroacetate

form

solid

form

-

form

powder

form

powder

assay

≥95%

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

color

white

color

-

color

white

color

white to off-white

biological source

synthetic

biological source

-

biological source

-

biological source

-

Application

CGP-42112A has been used:
  • in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
  • to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
  • as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

Biochem/physiol Actions

CGP-42112A is a potent angiotensin II type 2 receptor (AT2R) agonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000511932
0000511932
0000484342
0000484342
0000492066

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Claudia A McCarthy et al.
Hypertension (Dallas, Tex. : 1979), 60(6), 1531-1537 (2012-10-24)
We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor (AT(2)R) agonist is neuroprotective against a subsequent stroke independent of any changes in blood pressure. Therefore, in the current study, we have examined the potential neuroprotective effect
Liping Zhu et al.
American journal of physiology. Heart and circulatory physiology, 302(12), H2553-H2559 (2012-04-24)
ANG II type 2 receptors (AT(2)R) elicit cardioprotective effects in part by stimulating the release of kinins; however, the mechanism(s) responsible have not been fully explored. We demonstrated previously that overexpression of AT(2)R increased expression of prolylcarboxypeptidase (PRCP; a plasma
Francesca Sbrana et al.
American journal of physiology. Cell physiology, 295(1), C160-C172 (2008-05-16)
Membrane-cytoskeleton interaction regulates transmembrane currents through stretch-activated channels (SACs); however, the mechanisms involved have not been tested in living cells. We combined atomic force microscopy, confocal immunofluorescence, and patch-clamp analysis to show that stress fibers (SFs) in C2C12 myoblasts behave
L Laflamme et al.
The Journal of biological chemistry, 271(37), 22729-22735 (1996-09-13)
In the present study, 3-day treatment of nondifferentiated NG108-15 cells with 100 nM angiotensin II (Ang II) induces morphological differentiation of neuronal cells characterized by the outgrowth of neurites. These morphological changes are correlated with an increase in the level
C Sumners et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(17), 7567-7571 (1991-09-01)
Both neurons and astrocytes contain specific receptors for angiotensin II (AII). We used selective ligands for the AT1 and AT2 types of AII receptors to investigate the expression of functional receptor subtypes in astrocyte cultures and neuron cultures from 1-day-old
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