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C8249

Cardamonin

≥98% (HPLC),  glycogen synthase kinase 3 (GSK3) inhibitor, powder

Synonym(s):

(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one, (8CI); Alpinetin chalcone, (E)-2′,4′-Dihydroxy-6′-methoxy-chalcone

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Size/SKUAvailabilityPrice
5 mg
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869,00 PLN
25 mg
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3.500,00 PLN

About This Item

Empirical Formula (Hill Notation):
C16H14O4
CAS Number:
Molecular Weight:
270.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

869,00 PLN


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Product Name

Cardamonin, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

light yellow to dark brown

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

SMILES string

O=C(/C=C/C1=CC=CC=C1)C2=C(O)C=C(O)C=C2OC

InChI

1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+

InChI key

NYSZJNUIVUBQMM-BQYQJAHWSA-N

Application

Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.
Cardamonin has been used as a standard in high performance liquid chromatography (HPLC) to analyze phenolic compounds in acacia honey samples.

Biochem/physiol Actions

Cardamonin is a calchone from Aplinia species (zingiberaceous plant species).
Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation.

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This Item
PHL80379681672SML1450
description

≥98% (HPLC)

description

phyproof® Reference Substance

description

The Wnt/β-catenin Inhibitor, Cardamonin, also referenced under CAS 19309-14-9, controls the biological activity of Wnt/β-catenin. This small molecule/inhibitor is primarily used for Cancer applications.

description

≥98% (HPCE)

form

powder

form

-

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥98.0% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPCE)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: ≥20 mg/mL

solubility

-

solubility

ethanol: 5 mg/mL, DMSO: 100 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

color

light yellow to dark brown

color

-

color

orange-yellow to amber

color

white to beige


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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