D3168

Duramycin from Streptoverticillium cinnamoneus

≥90.0%

• Synonym(s): Duramycin, Lancovutide
• Empirical Formula (Hill Notation): C₈₉H₁₂₅N₂₃O₂₅S₃
• CAS Number: 1391-36-2
• Molecular Weight: 2013.28
• UNSPSC Code: 51102829
• NACRES: NA.85
• MDL number: MFCD00133301

Properties

• Quality Level: 200
• assay: ≥90.0%
• form: powder
• solubility: 0.1 M HCl: 10 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C

Description

General description

Chemical structure: tetracycline

Application

Duramycin is used to study chloride secretion by cardial, pancreatic and airway epithelial voltage-gated ion channels. It is used to study cystic fibrosis and as a novel phosphatidylethanolamine-binding molecular probe[1]. It is used to stimulate sodium transport in cultured human colonic epithelia[2].

Biochem/physiol Actions

Duramycin is the smallest known polypeptide since it has only 19 amino acids. It has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity[1]. It enhances chloride secretion in airway epithelium.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)