F100

Fluspirilene

• Synonym(s): 8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one, R 6218
• Empirical Formula (Hill Notation): C₂₉H₃₁F₂N₃O
• CAS Number: 1841-19-6
• Molecular Weight: 475.57
• NACRES: NA.77
• PubChem Substance ID: 24277915
• UNSPSC Code: 12352200
• EC Number: 217-418-6
• MDL number: MFCD00055137
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• assay: ≥98% (HPLC)
• Quality Segment: 200
• form: solid
• color: white
• solubility: DMSO: ≥20 mg/mL, H₂O: insoluble, ethanol: soluble
• originator: Johnson & Johnson
• storage temp.: room temp
• SMILES string: Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5
• InChI: 1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)
• InChI key: QOYHHIBFXOOADH-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Description

Application

Fluspirilene has been used as a neuroleptic drug to study its effects on human ether-a-go-go related gene (HERG).

Fluspirilene has been used to study its cytotoxicity effect on malignant glioma.

Biochem/physiol Actions

Fluspirilene has a potential to inhibit the activity of cyclin-dependent kinase 2 (CDK2). It is an effective anti-cancer agent used for treating human hepatocellular carcinoma.

Fluspirilene is a dopamine receptor antagonist. It also acts as a calcium channel blocker. Fluspirilene is an antipsychotic agent and exhibits neuoleptic properties. It exhibits therapeutic effects against glioblastoma and Schizophrenia.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)