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Fumagillin

Name: Fumagillin
Brand: SIGMA
Price: 1210 PLN

from Aspergillus sp. (Aspergillus fumigatus), ≥90% (HPLC), powder, MetAP2 inhibitor

Synonym(s):

Fugillin

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Size/SKU	Availability	Price
1 mg	Please contact Customer Service for Availability	1.210,00 PLN
5 mg	Please contact Customer Service for Availability	5.030,00 PLN

About This Item

Empirical Formula (Hill Notation):

C₂₆H₃₄O₇

CAS Number:

23110-15-8

Molecular Weight:

458.54

UNSPSC Code:

12352200

PubChem Substance ID:

24894920

NACRES:

NA.77

EC Number:

245-433-8

MDL number:

MFCD03990453

Assay:

≥90%

Form:

powder

1.210,00 PLN

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Properties

Product Name

Fumagillin from Aspergillus fumigatus, ≥90%, powder

biological source

Aspergillus sp. (Aspergillus fumigatus)

Quality Segment

200

assay

≥90%

form

powder

color

white

mp

197-198 °C

solubility

ethanol: 1 mg/mL

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes

storage temp.

−20°C

SMILES string

COC1C(CCC2(CO2)C1C3(C)OC3C\C=C(\C)C)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O

InChI

1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+

InChI key

NGGMYCMLYOUNGM-HCNIIHBUSA-N

Description

General description

Fumagillin is a metabolic product of fungi. It is originally isolated from Aspergillus fumigatus.

Application

Fumagillin from Aspergillus fumigatus has been used:

in chick chorioallantoic membrane (CAM) assay to study the changes in protein expression in response to anti-angiogenic agent
to study its effects on the mortality of caged Nosema ceranae-infected honey bees- write in this way
as a positive control in in vitro and ex vivo studies

Biochem/physiol Actions

Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.

Fumagillin is known to be effective against microsporidian fungal infections.

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This Item	344845	10115	10065
Sigma-Aldrich F6771 Fumagillin from Aspergillus fumigatus	Sigma-Aldrich 344845 Fumagillin, Aspergillus fumigatus	Sigma-Aldrich 10115 Amyloglucosidase from Aspergillus niger	Sigma-Aldrich 10065 α-Amylase from Aspergillus oryzae
description ≥90%, powder	description Antiprotozoal agent and angiogenesis inhibitor.	description lyophilized, powder, ~70 U/mg	description powder, ~30 U/mg
assay ≥90%	assay ≥90% (HPLC)	assay -	assay -
form powder	form powder	form powder	form powder
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility ethanol: 1 mg/mL	solubility methanol: 5 mg/mL	solubility -	solubility -
color white	color white to off-white	color -	color -

Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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