Skip to Content
Merck

G8377

Guanosine 5′-monophosphate disodium salt hydrate

≥99%,from yeast, powder

Synonym(s):

5′-GMP-Na2, 5′-Guanylic acid disodium salt hydrate

Slide 1 of 1
Sign In to View Organizational & Contract Pricing.

Select a Size

500 MG

PLN 225.00

1 G

PLN 339.00

5 G

PLN 480.00

25 G

PLN 1,950.00

100 G

PLN 5,830.00

PLN 225.00

Please contact Customer Service for Availability

About This Item

Empirical Formula (Hill Notation):
C10H12N5Na2O8P · xH2O
CAS Number:
5550-12-9
Molecular Weight:
407.18 (anhydrous basis)
NACRES:
NA.51
PubChem Substance ID:
24895338
UNSPSC Code:
41106305
EC Number:
226-914-1
MDL number:
MFCD00151238
Beilstein/REAXYS Number:
3586801

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Guanosine 5′-monophosphate disodium salt hydrate, from yeast, ≥99%

InChI

1S/C10H14N5O8P.2Na.H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);;;1H2/q;2*+1;/p-2/t3-,5-,6-,9-;;;/m1.../s1

InChI key

MEKWJTZTMVQYSU-CYCLDIHTSA-L

SMILES string

O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

biological source

yeast

assay

≥99%

form

powder

solubility

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

Quality Level

200

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
G6129I4625852228
Guanosine 5′-monophosphate disodium salt hydrate from yeast, ≥99%

Sigma-Aldrich

G8377

Guanosine 5′-monophosphate disodium salt hydrate

Guanosine 3′,5′-cyclic monophosphate sodium salt ≥99% (HPLC), powder

Sigma-Aldrich

G6129

Guanosine 3′,5′-cyclic monophosphate sodium salt

Inosine 5′-monophosphate disodium salt hydrate from yeast, Grade III, ≥98% (HPLC)

Sigma-Aldrich

I4625

Inosine 5′-monophosphate disodium salt hydrate

2′-Deoxyguanosine 5′-monophosphate disodium salt hydrate ≥98%

Sigma-Aldrich

852228

2′-Deoxyguanosine 5′-monophosphate disodium salt hydrate

biological source

yeast

biological source

-

biological source

yeast

biological source

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

form

powder

form

powder

form

powder

form

solid

assay

≥99%

assay

≥99% (HPLC)

assay

≥98% (HPLC)

assay

≥98%

solubility

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

solubility

H2O: 50 mg/mL

solubility

water: 50 mg/mL, clear, colorless

solubility

-

storage temp.

room temp

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

Application

Guanosine 5′-monophosphate is suitable for use in:
  • the measurement of density and viscosity of nucleotide and along with the furanose sugar from 0.0004 to 0.0014mol/kg solution at 288.15, 293.15 and 298.15K at atmospheric pressure[1]
  • the detection and validation of a transcreener assay for detection of AMP- and GMP-producing enzymes[2]
  • the preparation of nucleotide standard during the quantitative profiling of nucleotides using capillary IC-MS/MS[3]

Biochem/physiol Actions

Guanosine 5′-monophosphate (GMP) is a ribonucleoside monophospate which upon phosphorylation to GTP becomes incorporated into ribonucleic acids (RNAs) by various RNA polymerase(s). Guanosine-5′-monophosphate (GMP) can be used to study modulation of glutamatergic neurotransmission.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000497796
0000497796
BCCN3400
0000367733
0000295415

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Robbin R Vernooij et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 24(22), 5790-5803 (2018-01-10)
The photodecomposition mechanism of trans,trans,trans-[Pt(N3 )2 (OH)2 (py)2 ] (1, py=pyridine), an anticancer prodrug candidate, was probed using complementary Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR), transient electronic absorption, and UV/Vis spectroscopy. Data fitting using Principal Component Analysis (PCA) and
Marcelo Ganzella et al.
Purinergic signalling, 8(1), 49-58 (2011-09-02)
Overstimulation of the glutamatergic system (excitotoxicity) is involved in various acute and chronic brain diseases. Several studies support the hypothesis that guanosine-5'-monophosphate (GMP) can modulate glutamatergic neurotransmission. The aim of this study was to evaluate the effects of chronically administered
Roberto Farina Almeida et al.
Pharmacology, biochemistry, and behavior, 96(3), 306-311 (2010-06-23)
The glutamatergic system has received considerable attention over the last few years as potential target to develop anxiolytic drugs. Guanine based purines (GBPs) play an important neurmodulatory effect in the glutamatergic system. Several studies have shown the ability of the
Simone Molz et al.
Neurochemical research, 30(1), 83-89 (2005-03-11)
Guanosine-5'-monophosphate (GMP) was evaluated as a neuroprotective agent against the damage induced by glutamate in rat hippocampal slices submitted to glucose deprivation. In slices maintained under physiological conditions, glutamate (0.01 to 10 mM), Kainate, alpha-amino-3-hydroxi-5-methylisoxazole-propionic acid (AMPA), N-methyl-D-aspartate (NMDA), 1S,3R-aminocyclopentane-1,3-dicarboxylic
Matt Staeben et al.
Assay and drug development technologies, 8(3), 344-355 (2010-02-18)
Screening of AMP- and GMP-producing enzymes such as phosphodiesterases (PDEs), ligases, and synthetases would be simplified by the ability to directly detect unmodified nucleoside monophosphates. To address this need, we developed polyclonal and monoclonal antibodies that recognize AMP and GMP
View All Related Papers

Protocols

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

LC/MS Analysis of Nucleotides SeQuant® ZIC®-cHILIC – Effect of pH

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service