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Merck

M1318

Milnacipran hydrochloride

≥98% (HPLC), solid

Synonym(s):

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride, F 2207, Midalcipran, Toledomin

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10 MG

PLN 1,150.00

50 MG

PLN 3,417.00

PLN 1,150.00

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About This Item

Empirical Formula (Hill Notation):
C15H22N2O · HCl
CAS Number:
101152-94-7
Molecular Weight:
282.81
NACRES:
NA.77
PubChem Substance ID:
329817868
UNSPSC Code:
12352200
MDL number:
MFCD00901293

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Product Name

Milnacipran hydrochloride, ≥98% (HPLC), solid

InChI

1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/m1./s1

SMILES string

Cl[H].CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)c2ccccc2

InChI key

XNCDYJFPRPDERF-PBCQUBLHSA-N

description

Relative stereochemistry
Store with desiccants

assay

≥98% (HPLC)

form

solid

color

white

solubility

H2O: 19 mg/mL

originator

Cypress Bioscience

storage temp.

2-8°C

Quality Level

100

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Show Differences

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This Item
A7606C0742SML0893
Milnacipran hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

M1318

Milnacipran hydrochloride

Aprindine hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

A7606

Aprindine hydrochloride

CKI-7 dihydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

C0742

CKI-7 dihydrochloride

M8-B hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0893

M8-B hydrochloride

form

solid

form

solid

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

H2O: 19 mg/mL

solubility

H2O: >10 mg/mL

solubility

H2O: >5 mg/mL

solubility

H2O: 2 mg/mL, clear (warmed)

color

white

color

-

color

white to light tan

color

white to beige

Biochem/physiol Actions

Serotonin and norepinephrine reuptake inhibitor (SNRI)

Features and Benefits

This compound was developed by Cypress Bioscience. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000207768
0000207768
0000161091
0000158510
0000153707

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David T Wong et al.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 58, 169-222 (2002-06-25)
Preclinical and clinical studies support the rationale that development of single molecules, which would promote serotonergic and noradrenergic neurotransmission by inhibiting simultaneously the uptake of both monoamines, would potentially result in improved antidepressant drugs. Currently, the dual inhibitors of serotonin
C Moret et al.
Neuropharmacology, 24(12), 1211-1219 (1985-12-01)
The present study of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane(Z) hydrochloride, was undertaken to determine its biochemical profile. The properties of midalcipran, in inhibiting the uptake of monoamines were tested and compared with that of imipramine. In vitro, midalcipran was found to
Tsugunobu Andoh et al.
Biological & pharmaceutical bulletin, 43(7), 1111-1117 (2020-07-03)
Patients with cholestatic liver diseases, such as primary biliary cirrhosis, usually suffer from pruritus. However, the pathogenesis of cholestatic pruritus is unclear, and there is no current effective treatment for it. In order to find a treatment for the condition
P Okkerse et al.
European journal of pain (London, England), 21(3), 494-506 (2016-09-22)
Serotonin-norepinephrine reuptake inhibitors inhibit the reuptake of serotonin and noradrenalin and are used in the treatment of neuropathic pain. Animal studies suggest that milnacipran co-administered with opioids may potentiate the analgesic effect of μ-opioid receptor agonists. This study hypothesized that
Junji Uno et al.
Pharmacology, 99(1-2), 89-98 (2016-10-25)
To investigate the potential inhibitory effects of 18 clinically available antidepressants on acetylcholine (ACh)-induced contractions in guinea pig urinary bladder smooth muscle (UBSM) in order to predict whether they may induce voiding impairment. Concentration-response curves for ACh-induced contractions in guinea
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