This product is stable if kept as a powder in the freezer. It falls under our general warranty, which is one year from date of shipment. It is a biodegradable polymer, but the degradation rate when it is used depends on many parameters, such as the pH and temperature of the surroundings, as well as the accessibility of the polymer (e.g., whether encapsulated or not).
P1941
Poly(D,L-lactide-co-glycolide)
lactide:glycolide (75:25), mol wt 66,000-107,000
Synonym(s):
LACTEL® B6007-1, PLGA
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1 G
PLN 820.00
5 G
PLN 2,850.00
About This Item
Linear Formula:
[C3H4O2]x[C2H2O2]y
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.26
MDL number:
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Product Name
Poly(D,L-lactide-co-glycolide), lactide:glycolide (75:25), mol wt 66,000-107,000
InChI key
XBBVURRQGJPTHH-UHFFFAOYSA-N
SMILES string
OCC(O)=O.CC(O)C(O)=O
form
pellets
feed ratio
lactide:glycolide (75:25)
mol wt
66,000-107,000
storage temp.
−20°C
Quality Level
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1 of 4
This Item | P2066 | 430471 | 802182 |
|---|---|---|---|
| form pellets | form pellets | form amorphous | form solid |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| feed ratio lactide:glycolide (75:25) | feed ratio lactide:glycolide 65:35 | feed ratio lactide:glycolide 85:15 | feed ratio lactide:glycolide (50:50) |
| mol wt 66,000-107,000 | mol wt Mw 40,000-75,000 | mol wt Mw 50,000-75,000 | mol wt average Mw 100,000 |
Application
Poly(D,L-lactide-co-glycolide) is a synthetic amino acid that has been used to deliver macromolecular therapeutics.[1]
Features and Benefits
Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.
General description
The product is an amorphous solid with a transition temperature (Tg) in the range of 45-50°C. It is soluble in most organic solvents such as methylene chloride, tetrahydrofuran, ethyl acetate, acetone, chloroform, and hexafluoroispropanol.
Physical form
Biocompatible, biodegradable polymer.
Legal Information
Lactel is a registered trademark of Evonik Corp
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures
Articles
Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.
Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.
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What is degradation rate of this product?
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Can this product (P1941) form a hydrogel?
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The molecular weight of poly(lactic-co-glycolic acid) (PLGA) significantly influences its properties, including the ability to form hydrogels. Generally, lower molecular weight PLGA materials (around 5,000 to 20,000 g/mol) tend to form hydrogels more readily compared to higher molecular weight counterparts. This is because lower molecular weight PLGA has a higher chain mobility, which facilitates the formation of physical or chemical crosslinks necessary for hydrogel formation. It may be more suitable to use product 805726 or P2191, which are not only a lower molecular weight but also a higher proportion of glycolic acid. This makes for a more hydrophilic polymer, thus enhancing water absorption and swelling properties, making it more suitable for hydrogel applications.
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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Is this product (P1941) acid terminated or ester terminated?
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The product is ester terminated.
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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What is solubility information of plga 75:25
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The solubility of this product is not determined. However, various sources state that Poly(D, L-lactide-co-glycolide) is soluble in organic solvents such as methylene chloride, tetrahydrofuran, ethyl acetate, acetone, chloroform, and hexafluoroisopropanol. The concentration has not been determined for these solvents.
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