P7136
Pyrazinecarboxamide
Synonym(s):
Pyrazinamide, Pyrazinoic acid amide
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| Size/SKU | Availability | Price |
|---|---|---|
10 g | Please contact Customer Service for Availability | 343,00 PLN |
25 g | Please contact Customer Service for Availability | 489,00 PLN |
100 g | Please contact Customer Service for Availability | 1.630,00 PLN 1.385,50 PLN |
About This Item
Empirical Formula (Hill Notation):
C5H5N3O
CAS Number:
Molecular Weight:
123.11
UNSPSC Code:
41116107
NACRES:
NA.85
PubChem Substance ID:
EC Number:
202-717-6
Beilstein/REAXYS Number:
112306
MDL number:
form
powder
Quality Segment
mp
189-191 °C (lit.)
antibiotic activity spectrum
mycobacteria
mode of action
cell membrane | interferes
SMILES string
NC(=O)c1cnccn1
InChI
1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
InChI key
IPEHBUMCGVEMRF-UHFFFAOYSA-N
Application
Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention and mechanisms of resistance .
Biochem/physiol Actions
The active moiety of pyrazinamide is pyrazinoic acid (POA). POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis. Iron enhances the antituberculous activity of pyrazinamide . Pyrazinamide and its analogs have been shown to inhibit the activity of purified FAS I.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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This Item | |||
|---|---|---|---|
| description - | description United States Pharmacopeia (USP) Reference Standard | description Pharmaceutical Secondary Standard; Certified Reference Material | description British Pharmacopoeia (BP) Reference Standard |
| mode of action cell membrane | interferes | mode of action - | mode of action - | mode of action - |
| antibiotic activity spectrum mycobacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level - | Quality Level 300 | Quality Level - |
| form powder | form - | form - | form crystalline |
| mp 189-191 °C (lit.) | mp 189-191 °C (lit.) | mp 189-191 °C (lit.) | mp 189-191 °C (lit.) |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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