The solubility specification was tested at 100 mg/ml in 1 M NaOH (refer to the specification sheet). Probenecid is soluble in chloroform, in dilute solutions of sodium hydroxide, then buffered to pH 7.4, and is nearly insoluble in water. It is also soluble in 1 M NaOH (50 mg/ml), producing a clear, colorless solution.
P8761
Probenecid
≥98% (NaOH, titration), powder, uricosuric agent
Synonym(s):
p-(Dipropylsulfamoyl)benzoic acid
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25 G
PLN 656.00
100 G
PLN 1,780.00
About This Item
Empirical Formula (Hill Notation):
C13H19NO4S
CAS Number:
Molecular Weight:
285.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
200-344-3
MDL number:
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Product Name
Probenecid,
InChI key
DBABZHXKTCFAPX-UHFFFAOYSA-N
InChI
1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
SMILES string
CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
assay
≥98% (NaOH, titration)
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level
Gene Information
human ... SLC22A11(55867), SLC22A6(9356), SLC22A8(9376)
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Related Categories
1 of 4
This Item | 1563003 | P3000000 | PHR2608 |
|---|---|---|---|
| assay ≥98% (NaOH, titration) | assay - | assay - | assay - |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level 300 |
| originator Merck & Co., Inc., Kenilworth, NJ, U.S. | originator - | originator - | originator - |
| Gene Information human ... SLC22A11(55867), SLC22A6(9356), SLC22A8(9376) | Gene Information human ... SLC22A11(55867), SLC22A6(9356), SLC22A8(9376) | Gene Information human ... SLC22A11(55867), SLC22A6(9356), SLC22A8(9376) | Gene Information - |
Application
Probenecid has been used:
- as a component of phenol red free Hank′s buffer for Intracellular Ca2+-mobilization assay[1]
- as a component of calcium sensitive dye for calcium mobilization Studies[2]
- as a supplement in Hank′s balanced salt solution (HBSS) assay buffer[3]
Useful as an inhibitor of the organic anion transporter, MRP.
Biochem/physiol Actions
Probenecid is a uricosuric agent, which increases uric acid removal in the urine[4] and reduces urate reuptake.[5] It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout.[5] Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma.[4]
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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The
Drugs of Abuse: Neurological Reviews and Protocols, 109-109 (2003)
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice
Tang X, et al.
Journal of Lipid Research, 55, 2389-2400 (2014)
Determining the potency and molecular mechanism of action of insurmountable antagonists.
Kenakin, T, et al.
Journal of Pharmacology and Experimental Therapeutics, 319, 710-723 (2014)
Probenecid, a gout remedy, inhibits pannexin 1 channels
Harris D, et al.
American Journal of Physiology. Cell Physiology, 295, C761?C767-C761?C767 (2008)
The long duration of action of the second generation antihistamine bilastine coincides with its long residence time at the histamine H1 receptor
Bosma R, et al.
European Journal of Pharmacology, 838, 107-111 (2018)
Articles
Protein-based drug transporters are expressed in Sf9 cells. Understanding the specific mechanisms of tumor cell transporters is an essential aspect of chemotherapeutic drug design.
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