RAB0697

Human IL23A / Interleukin-23 Subunit Alpha ELISA Kit

Name: Human IL23A / Interleukin-23 Subunit Alpha ELISA Kit
Brand: SIGMA
Price: 2760 PLN

for serum, plasma, cell culture supernatants and urine

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96 WELLS

PLN 2,760.00

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About This Item

NACRES:

NA.32

UNSPSC Code:

41116158

Key Documents

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Product Name

Human IL23A / Interleukin-23 Subunit Alpha ELISA Kit, for serum, plasma, cell culture supernatants and urine

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type serum
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 25 pg/mL
standard curve range: 28.67-7000 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL23A(51561)

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1 of 4

This Item	RAB1524	RAB0693	RAB0681
Sigma-Aldrich RAB0697 Human IL23A / Interleukin-23 Subunit Alpha ELISA Kit	Sigma-Aldrich RAB1524 Human IL-23 R ELISA	Sigma-Aldrich RAB0693 Human IL2RA / Interleukin-2 Receptor Subunit Beta ELISA Kit	Sigma-Aldrich RAB0681 Human IL13RA1 / Interleukin-13 Receptor Subunit Alpha-1 ELISA Kit
Gene Information human ... IL23A(51561)	Gene Information human ... IL23R(149233)	Gene Information human ... IL2RA(3559)	Gene Information human ... IL13RA1(3597)
species reactivity human	species reactivity human	species reactivity human	species reactivity human
input sample type cell culture supernatant(s) sample type serum sample type plasma	input sample type serum sample type cell culture supernatant(s) sample type plasma	input sample type cell culture supernatant(s) sample type serum sample type plasma	input sample type cell culture supernatant(s) sample type serum sample type plasma
assay range inter-assay cv: <12% intra-assay cv: <10% sensitivity: 25 pg/mL standard curve range: 28.67-7000 pg/mL	assay range inter-assay cv: <12% intra-assay cv: <10% sensitivity: 0.2 ng/mL standard curve range: 0.205-50 ng/mL	assay range inter-assay cv: <12% intra-assay cv: <10% sensitivity: 22 pg/mL standard curve range: 24.58-6000 pg/mL	assay range inter-assay cv: <12% intra-assay cv: <10% sensitivity: 0.042 ng/mL standard curve range: 0.041-10 ng/mL
technique(s) ELISA: suitable	technique(s) ELISA: suitable	technique(s) ELISA: suitable	technique(s) ELISA: suitable
detection method colorimetric	detection method colorimetric	detection method colorimetric	detection method colorimetric

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Interleukin-23 (IL-23) plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity driving the expansion, stabilization and survival of Th17 cells.[1]

General description

Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated DC (dendritic cells) and macrophages.[1] It is a 20.7 kDa protein that has 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.[2]

The IL23A ELISA kit provides for the Quantitative measurement of IL-23 in Cell Culture Supernatants, Plasma and Serum.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

pictograms

GHS05

signalword

Warning

hcodes

H290

pcodes

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

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HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP.

Paola Miyazato et al.

Retrovirology, 16(1), 38-38 (2019-12-18)

Human T cell leukaemia virus type 1 (HTLV-1) is a retrovirus associated with human diseases such as adult T-cell leukaemia/lymphoma and HTLV-1 associated myelopathy/tropical spastic paraparesis. In contrast to another human retrovirus, human immunodeficiency virus type 1 (HIV-1), HTLV-1 persists

Accumulation of FLT3(+) CD11c (+) dendritic cells in psoriatic lesions and the anti-psoriatic effect of a selective FLT3 inhibitor.

Heng-Xiu Yan et al.

Immunologic research, 60(1), 112-126 (2014-06-05)

Psoriasis is a common chronic T-cell-mediated autoimmune skin disease, and traditional immunotherapies for psoriasis have focused on the direct inhibition of T cells, which often causes toxicity and lacks long-term effectiveness. Safe and effective therapeutic strategies are strongly needed for

The Selenoprotein MsrB1 Instructs Dendritic Cells to Induce T-Helper 1 Immune Responses.

Ho-Jae Lee et al.

Antioxidants (Basel, Switzerland), 9(10) (2020-10-24)

Immune activation associates with the intracellular generation of reactive oxygen species(ROS). To elicit effective immune responses, ROS levels must be balanced. Emerging evidenceshows that ROS-mediated signal transduction can be regulated by selenoproteins such asmethionine sulfoxide reductase B1 (MsrB1). However, how

Adjuvant Activity of Synthetic Lipid A of Alcaligenes, a Gut-Associated Lymphoid Tissue-Resident Commensal Bacterium, to Augment Antigen-Specific IgG and Th17 Responses in Systemic Vaccine.

Yunru Wang et al.

Vaccines, 8(3) (2020-07-24)

Alcaligenes spp. are identified as commensal bacteria and have been found to inhabit Peyer's patches in the gut. We previously reported that Alcaligenes-derived lipopolysaccharides (LPS) exerted adjuvant activity in systemic vaccination, without excessive inflammation. Lipid A is one of the

Interleukin-17 and interleukin-23: importance in the pathogenesis of lung impairment in patients with systemic sclerosis.

Anna Olewicz-Gawlik et al.

International journal of rheumatic diseases, 17(6), 664-670 (2014-01-29)

T cell abnormalities with a focus on Th17 cells have been associated with the pathogenesis of systemic sclerosis (SSc) and interstitial lung disease (ILD). The aim of this study was to evaluate serum levels of interleukin (IL)-17, IL-21 and IL-23

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