RAB1122

Mouse EPO ELISA Kit

for cell culture supernatants, plasma, and serum samples

• NACRES: NA.32
• UNSPSC Code: 41116158
• Gene information: mouse ... Epo(13856)
• Input: sample type cell culture supernatant(s); sample type plasma; sample type serum sample(s)
• Species reactivity: mouse
• Storage temp.: −20°C
• Shipped in: wet ice

Properties

• species reactivity: mouse
• packaging: kit of 96 wells (12 strips x 8 wells)
• technique(s): ELISA: suitable
• input: sample type cell culture supernatant(s); sample type plasma; sample type serum sample(s)
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 1.5 pg/ml
• detection method: colorimetric
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... Epo(13856)

Description

General description

This ELISA antibody pair detects Mouse Erythropoietin (EPO)

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

Erythropoietin (EPO) is a glycoprotein hormone which is essential for the proliferation of erythropoietic progenitors to produce red blood cells (RBCs). Peritubular fibroblast in kidney cortex is the primary site for EPO production in adults, though spleen, bone marrow and liver contribute to the production. In fetus, liver is the primary site for EPO production. Additionally, EPO functions in some cytoprotective activities like, antiapoptotic, antioxidant, and anti-inflammatory responses. Hypoxia inducible factors upregulate EPO expression. EPO expression increases with decreased hemoglobin concentration in few cases of anemia. Decreased production of EPO is the cause of anemia in chronic kidney diseases. Circulating endogenous antibodies to EPO (anti-EPO) is the cause of anemia in multiple diseases like human immunodeficiency virus (HIV) infection, hepatitis C virus infection, systemic lupus erythematosus. Gain-of-function polymorphism in EPO causes familial erythrocytosis.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Storage Class: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• Hazard Codes: H334
• Precautionary Statements: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1