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Merck

SML0885

bpV(pic)

≥95% V basis

Synonym(s):

Dipotassium Bisperoxovanadium(pic) dihydrate, Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate, K2 [VO(O2)2C6H4NO2] · 2 H2O

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5 MG

PLN 455.00

25 MG

PLN 1,540.00

PLN 455.00

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About This Item

Empirical Formula (Hill Notation):
K2VOO2O2C6H4NO2 · 2H2O
CAS Number:
148556-27-8
Molecular Weight:
367.27
UNSPSC Code:
12352200
NACRES:
NA.77

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Quality Level

100

Assay

≥95% V basis

form

powder

storage condition

protect from light

color

faintly yellow to dark yellow

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

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This Item
SML0884SML0889203694
bpV(pic) ≥95% V basis

Sigma-Aldrich

SML0885

bpV(pic)

bpV(HOpic) ≥90% V basis

Sigma-Aldrich

SML0884

bpV(HOpic)

bpV(phen) ≥95% V basis

Sigma-Aldrich

SML0889

bpV(phen)

bpV(bipy) A potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor dephosphorylation).

Sigma-Aldrich

203694

bpV(bipy)

form

powder

form

powder

form

powder

form

solid

assay

≥95% V basis

assay

≥90% V basis

assay

≥95% V basis

assay

≥95% (51V-NMR)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

H2O: 20 mg/mL, clear

solubility

H2O: 20 mg/mL, clear

solubility

H2O: 20 mg/mL, clear

solubility

water: 5 mg/mL

storage condition

protect from light

storage condition

desiccated, protect from light

storage condition

protect from light

storage condition

OK to freeze, protect from light

Application

bpV(pic) has been used in cell culture treatment to study the route of activation of multiple pathways required for HERV (human endogenous retroviruses) transcription.[1]

Biochem/physiol Actions

bpV(pic) contains a polar side chain, and specifically inhibits PTEN(phosphatase and tensin homolog) unlike its parent compound, which targets several other phosphatases too. Thus, making bpV(pic) more a prefered inhibitor.[2] bpV(pic) is recognized as a potent activator of multiple sclerosis (an autoimmune disorder) related human endogenous retroviruses.[1]
bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).
bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN).

Other Notes

Light Sensitive

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000476149
0000476149
0000217421
0000118781
0000118783

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Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair.
Lai J P, et al.
British Journal of Pharmacology, 152(8), 1172-1184 (2007)
Compound signaling activates endogenous retroviruses by inducing enhancer and gene-neighborhood transcription.
Azebi S, et al.
bioRxiv, 284695 (2018)
Xiaodong Wu et al.
CNS neuroscience & therapeutics, 29(11), 3598-3611 (2023-06-13)
Neuronal abnormalities are closely associated with major depressive disorder (MDD). Available evidence suggests a role for microRNAs (miRNAs) in regulating the expression of genes involved in MDD. Hence, miRNAs that can be potential therapeutic targets need to be identified. A
Ali A Shati et al.
Clinical and experimental pharmacology & physiology, 49(2), 275-290 (2021-09-28)
This study evaluated the protective effect of resolvin D1 (RVD1) against cadmium chloride (CdCl2 )-induced hippocampal damage and memory loss in rats and investigated if such protection is mediated by modulating the PTEN/PI3K/Akt/mTOR pathway. Adult male Wistar rats (n =
Qian Chen et al.
Journal of inflammation research, 15, 2707-2720 (2022-05-04)
This study aims to investigate the cytoprotective and anti-inflammatory effects of an α2-adrenoreceptor (α2-AR) agonist, dexmedetomidine (Dex), on lipopolysaccharides (LPS)-induced acute lung injury and underlying mechanisms with focus on alveolar macrophage polarization modulation. C57BL/6 mice were intraperitoneally injected LPS (10
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