SML4366

Lasmiditan hemisuccinate

≥98% (HPLC)

• Synonym(s): 2,4,6-Trifluoro-N-[6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl]benzamid hemisuccinate, 2,4,6-Trifluoro-N-[6-[(1-methylpiperidin-4-yl)carbonyl]pyridin-2yl]benzamide hemisuccinate, COL 144 hemisuccinate, COL-144 hemisuccinate, COL144 hemisuccinate, LY 573144 hemisuccinate, LY-573144 hemisuccinate, LY573144 hemisuccinate
• Empirical Formula (Hill Notation): C₃₈H₃₆F₆N₆O₄·C₄H₆O₄
• CAS Number: 439239-92-6
• Molecular Weight: 872.81
• UNSPSC Code: 12352200
• MDL number: MFCD31728527
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• drug control: USDEA Schedule V
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Description

Biochem/physiol Actions

Lasmiditan (COL-144 and LY573144) is an orally active, potent and selective high-affinity serotonin receptor 5-HT1F agonist (5-HT1F/1E Ki = 2.21/594 nM; 5-HT1A/B/C Ki >1 μM; 5-HT2A/B/C Ki >2 μM; 5-HT6/7 Ki >3 μM). Lasmiditan induces mitochondrial biogenesis (MB) in human glomerular endothelial cells and mouse glomerular endothelial cells (100 nM for 72h). Unlike the triptans, Lasmiditan is void of vasoconstrictor activity toward isolated human coronary arteries (up to 100 μM) or in anaesthetized female beagle dogs in vivo (4.13-11.13 mg/kg i.v.)

Disclaimer

Hygroscopic, Store with desiccant

Safety Information

• Pictograms: GHS08,GHS05,GHS07
• Signal Word: Danger
• Hazard Codes: H302,H318,H336,H361fd
• Precautionary Statements: P202 - P261 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class: 11 - Combustible Solids