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Merck

T1330

Tamsulosin hydrochloride

≥98% (HPLC)

Synonym(s):

5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

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10 MG

PLN 579.00

50 MG

PLN 1,980.50

PLN 579.00

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About This Item

Empirical Formula (Hill Notation):
C20H28N2O5S · HCl
CAS Number:
106463-17-6
Molecular Weight:
444.97
MDL number:
MFCD00922997
UNSPSC Code:
12352200
PubChem Substance ID:
329826665
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: >10 mg/mL

originator

Boehringer Ingelheim

storage temp.

room temp

SMILES string

Cl.CCOc1ccccc1OCCN[C@H](C)Cc2ccc(OC)c(c2)S(N)(=O)=O

InChI

1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1

InChI key

ZZIZZTHXZRDOFM-XFULWGLBSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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Show Differences

1 of 4

This Item
PHR15241643260R9281
Tamsulosin hydrochloride ≥98% (HPLC)

Sigma-Aldrich

T1330

Tamsulosin hydrochloride

Tamsulosin hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1524

Tamsulosin hydrochloride

Tamsulosin hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1643260

Tamsulosin hydrochloride

Rotigotine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

R9281

Rotigotine hydrochloride

assay

≥98% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

form

powder

form

-

form

-

form

solid

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

100

storage temp.

room temp

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

room temp

solubility

DMSO: >10 mg/mL

solubility

-

solubility

-

solubility

DMSO: >10 mg/mL

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

desiccated

Biochem/physiol Actions

Tamsulosin is a α1A/1D-adrenoceptor antagonist; Used as a treatment of BPH (benign prostatic hypertrophy).
Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000514321
0000514321
0000457663
0000457663
0000118898

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Grzegorz Niemczyk et al.
BioMed research international, 2020, 6632359-6632359 (2021-01-01)
Bladder outlet obstruction (BOO) occurs in more than 20 percent of the adult population and may lead to changes in the structure and function of the bladder. The main objective of the study was to evaluate the expression of Toll-like
Shuo Yang et al.
The AAPS journal, 16(4), 860-871 (2014-05-31)
Multi-pellet formulations are advantageous for the controlled release of drugs over single-unit dosage forms. To understand the diffusion controlled drug release mechanism, the pellet structure and drug release from a single pellet (not at dose level) were studied using synchrotron
Nannan Chu et al.
Clinical therapeutics, 37(2), 462-472 (2014-12-04)
The primary aim of this study was to evaluate whether there was clinically significant pharmacokinetic (PK) interaction between finasteride and tamsulosin in healthy Chinese male subjects. This was an open-label, randomized, 3-period, crossover study. Subjects received single and multiple doses
Thomas Kunit et al.
American journal of physiology. Renal physiology, 307(7), F823-F832 (2014-07-25)
Smooth muscle contraction may be critical for lower urinary tract symptoms (LUTS) in patients with benign prostate hyperplasia and requires stable anchorage of the cytoskeleton to the cell membrane. These connections are regulated by focal adhesion kinase (FAK). Here, we
S Kimsakulvech et al.
Andrologia, 47(3), 354-359 (2014-04-02)
Male temporary contraception is occasionally required in some animals. Alpha1-adrenoceptor antagonist (tamsulosin) can cause ejaculation disorder. Two sets of Latin square were applied to six male goats to received either normal saline, dimethylsulphoxide or tamsulosin (179.8 nmol kg(-1) ) at 1-week interval.

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