The purity of this material is indicated by the dye content. The minimum dye content of this product is 65%. A brief review of recent lots indicates that 85 - 90% dye content is typical. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/543/093/t3516pis.pdf
T3516
Thioflavin T
Powder
Synonym(s):
Basic Yellow 1, Thioflavine T
Sign In to View Organizational & Contract Pricing.
Select a Size
5 G
PLN 341.00
25 G
PLN 656.00
About This Item
Empirical Formula (Hill Notation):
C17H19ClN2S
CAS Number:
Molecular Weight:
318.86
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
EC Number:
219-228-9
MDL number:
Colour Index Number:
49005
Beilstein/REAXYS Number:
3922452
Skip To
Product Name
Thioflavin T, used as stain for amyloid
InChI
1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
InChI key
JADVWWSKYZXRGX-UHFFFAOYSA-M
SMILES string
[Cl-].CN(C)c1ccc(cc1)-c2sc3cc(C)ccc3[n+]2C
form
powder
composition
Dye content, ≥65%
solubility
methanol: 1 mg/mL
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
Looking for similar products? Visit Product Comparison Guide
1 of 4
This Item | 596200 | T1892 | F6377 |
|---|---|---|---|
| application(s) diagnostic assay manufacturing | application(s) - | application(s) diagnostic assay manufacturing | application(s) diagnostic assay manufacturing |
| solubility methanol: 1 mg/mL | solubility water: 5 mg/mL | solubility ethanol: water (1:1): 1 mg/mL | solubility H2O: 1 mg/mL |
| form powder | form solid | form powder | form powder |
| storage temp. room temp | storage temp. 15-25°C | storage temp. room temp | storage temp. room temp |
| composition Dye content, ≥65% | composition - | composition - | composition - |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
Application
Thioflavin T has been used to identify the presence of amyloid fibrils in samples.[1]
General description
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Ritu Khurana et al.
Journal of structural biology, 151(3), 229-238 (2005-08-30)
Thioflavin T is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, thioflavin T was found to exist as micelles
Pai Peng et al.
Nucleic acids research, 45(2), 541-546 (2016-12-03)
We present a conceptually new reversible nanosensor regulated by a DNA nanoswitch. This system is not only responsive to external stimuli (e.g. ATP) but also can be reversibly switched between 'OFF' and 'ON' states via toehold mediated strand displacement reactions.
Matthew Biancalana et al.
Biochimica et biophysica acta, 1804(7), 1405-1412 (2010-04-20)
Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes. Since its first description in 1959, the fluorescent dye Thioflavin-T (ThT) has become among the most
Extrinsic fluorescent dyes as tools for protein characterization.
Hawe, A., et al.
Pharmaceut. Res., 25, 1487-1499 (2008)
Jian Xiong et al.
Biophysical chemistry, 220, 42-48 (2016-11-20)
The hydrophobic fragment of the Alzheimer's related β-amyloid (Aβ) peptide, Aβ(25-40), aggregates and forms insoluble amyloid fibrils at a rate similar to the full-length peptide. In order to gain insight into the fibrillization of Aβ(25-40) and the ability of the
Related Content
Product Information Sheet
-
How about the purity of this product?
1 answer-
Helpful?
-
-
How do you reconsititute the powder?
1 answer-
As described in the product data sheet, the product is soluble in methanol at 1mg/mL (0.1% w/v).
Please see the product data sheet for additional solubility and handling recommendations: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/543/093/t3516pis.pdfHelpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service