A1987

AM6545

≥98% (HPLC)

• Synonim(y): 5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide
• Wzór empiryczny (zapis Hilla): C₂₆H₂₃Cl₂N₅O₃S
• Numer CAS: 1245626-05-4
• Masa cząsteczkowa: 556.46
• NACRES: NA.77
• PubChem Substance ID: 329770727
• UNSPSC Code: 12352200
• MDL number: MFCD19053178
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >25 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(cc3)C#CCCC#N)C(=O)NN4CCS(=O)(=O)CC4
• InChI: 1S/C26H23Cl2N5O3S/c1-18-24(26(34)31-32-13-15-37(35,36)16-14-32)30-33(23-11-10-21(27)17-22(23)28)25(18)20-8-6-19(7-9-20)5-3-2-4-12-29/h6-11,17H,2,4,13-16H2,1H3,(H,31,34)
• InChI key: XBHQLFVDGLPBCK-UHFFFAOYSA-N

Opis

General description

AM6545 is a cannabinoid (CB1) receptor antagonist.

Biochem/physiol Actions

AM6545 is a peripheral CB1 cannabinoid receptor antagonist and appetite suppressant.

AM6545 helps in decreasing the development of albuminuria, inflammation and expression of markers of fibrosis. It also helps in the down-regulation of nephrin and podocin. It has the ability to repress the ingestion of food and food-reinforced behaviour.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H319
• Ostrzeżenia: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable