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Merck

C1919

Chloramphenicol

BioReagent, suitable for plant cell culture

Synonim(y):

D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide, Chloromycetin

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Wybierz wielkość

5 G

165,00 zł

25 G

395,25 zł

100 G

1317,50 zł

165,00 zł

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Informacje o tej pozycji

Wzór liniowy:
Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
Numer CAS:
56-75-7
Masa cząsteczkowa:
323.13
Beilstein:
2225532
Numer WE:
200-287-4
Numer MDL:
MFCD00078159
Kod UNSPSC:
51102831
Identyfikator substancji w PubChem:
24892448
NACRES:
NA.76

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linia produktu

BioReagent

Poziom jakości

200

Formularz

powder

metody

cell culture | plant: suitable

zanieczyszczenia

Endotoxin, tested

mp

149-153 °C (lit.)

spektrum działania antybiotyku

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

Zastosowanie

agriculture

Tryb działania

protein synthesis | interferes

temp. przechowywania

2-8°C

ciąg SMILES

OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O

InChI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1

Klucz InChI

WIIZWVCIJKGZOK-RKDXNWHRSA-N

informacje o genach

human ... CYP1A2(1544)

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Pokaż różnice

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Ta pozycja
31667BP854Y0001869
Chloramphenicol BioReagent, suitable for plant cell culture

Sigma-Aldrich

C1919

Chloramphenicol

Chloramphenicol VETRANAL®, analytical standard

Supelco

31667

Chloramphenicol

Chloramphenicol British Pharmacopoeia (BP) Reference Standard

BP854

Chloramphenicol

Chloramphenicol for peak identification European Pharmacopoeia (EP) Reference Standard

Y0001869

Chloramphenicol for peak identification

antibiotic activity spectrum

Gram-negative bacteria, mycobacteria, Gram-positive bacteria, mycoplasma

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

technique(s)

cell culture | plant: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

mode of action

protein synthesis | interferes

mode of action

-

mode of action

-

mode of action

-

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

-

product line

BioReagent

product line

VETRANAL®

product line

-

product line

-

form

powder

form

-

form

powder

form

-

Opis ogólny

Chemical structure: phenicole

Zastosowanie

Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.

Działania biochem./fizjol.

Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.

Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.

Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.

Uwaga dotycząca przygotowania

Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place, Light sensitive. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Oświadczenie o zrzeczeniu się odpowiedzialności

Stock solutions should be stored at 2-8°C and are stable at 37°C for 5 days. Aqueous solutions are neutral and stable over a wide pH range, with 50% hydrolysis occurring after 290 days. Use of a borax buffered solution reduces this number to 14%. Solutions should be protected from light as photochemical decomposition results in a yellowing of the solution. Heating aqueous solutions at 115°C for 30 minutes results in a 10% loss of chloramphenicol.
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Piktogramy

Health hazardCorrosion
GHS08,GHS05

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H318,H351,H361fd

Zwroty wskazujące środki ostrożności

P202 - P280 - P305 + P351 + P338 - P308 + P313 - P405 - P501

Klasyfikacja zagrożeń

Carc. 2 - Eye Dam. 1 - Repr. 2

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Środki ochrony indywidualnej

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
0000474737
0000474737
0000458073
0000458073
0000451673

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Maiken Cavling Arendrup et al.
The Journal of antimicrobial chemotherapy, 75(7), 1807-1819 (2020-04-18)
Terbinafine resistance is increasingly reported in Trichophyton, rendering susceptibility testing particularly important in non-responding cases. We performed a multicentre evaluation of six EUCAST-based methods. Ten laboratories susceptibility tested terbinafine, itraconazole, voriconazole and amorolfine against a blinded panel of 38 terbinafine
Anthony J Brzoska et al.
PloS one, 8(2), e56090-e56090 (2013-02-15)
Members of the genus Acinetobacter have been the focus recent attention due to both their clinical significance and application to molecular biology. The soil commensal bacterium Acinetobacter baylyi ADP1 has been proposed as a model system for molecular and genetic
David G Kirk et al.
Applied and environmental microbiology, 80(16), 5141-5150 (2014-06-15)
Clostridium botulinum produces heat-resistant endospores that may germinate and outgrow into neurotoxic cultures in foods. Sporulation is regulated by the transcription factor Spo0A and the alternative sigma factors SigF, SigE, SigG, and SigK in most spore formers studied to date.
J N de Almeida Júnior et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(8), 784-790 (2013-12-21)
Trichosporon spp. have recently emerged as significant human pathogens. Identification of these species is important, both for epidemiological purposes and for therapeutic management, but conventional identification based on biochemical traits is hindered by the lack of updates to the species
David H Kwan et al.
Journal of the American Chemical Society, 137(17), 5695-5705 (2015-04-15)
Blood transfusions are critically important in many medical procedures, but the presence of antigens on red blood cells (RBCs, erythrocytes) means that careful blood-typing must be carried out prior to transfusion to avoid adverse and sometimes fatal reactions following transfusion.
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Produkty

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Krzywa zabijania antybiotyków to eksperyment dawka-odpowiedź, w którym komórki ssaków są poddawane rosnącej ilości antybiotyku selekcyjnego.

Antibiotic Kill Curve

Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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